KCNJ6 anticorps (C-Term)

N° du produit ABIN374875

Cet anticorps Chèvre Polyclonal détecte spécifiquement KCNJ6 dans WB. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour KCNJ6 anticorps (C-Term) (ABIN374875)

Antigène: KCNJ6 (Potassium Inwardly-Rectifying Channel, Subfamily J, Member 6 (KCNJ6))

Reactivité: Humain, Souris, Rat

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp KCNJ6 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-KCNJ6 anticorps

Épitope: C-Term

Séquence: C-SSKLNQHAEL ET

Specificité: This antibody detects KCNJ6.

Réactivité croisée (Details): Species reactivity (expected):Mouse, RatSpecies reactivity (tested):Human

Purification: Ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.

Immunogène: Peptide from the C Terminus of the protein sequence according to NP_002231.1 Genename: KCNJ6

Information d'application

Indications d'application: Peptide ELISA: limit dilution 1: 16000. Western blot: 1-3 μg/mL. Approx 48 kDa band observed in Human Brain (Hippocampus andSubstantia Nigra) lysates (calculated MW of 48.8 kDa according to NP_002231.1). Anadditional band of unknown identity was also consistently observed at 38 kDa. This bandwas successfully blocked by incubation with the immunising peptide. We would appreciateany feedback from people in the field - have any such results been reported with otherantibodies/lysates? Have any further splice variants/modified forms been reported?
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.

Détails sur KCNJ6

Antigène: KCNJ6 (Potassium Inwardly-Rectifying Channel, Subfamily J, Member 6 (KCNJ6))

Autre désignation: KCNJ6

Sujet: G-protein regulated inward-rectifier potassium channels (GIRK) are part of a superfamily of inward-rectifier K+ channels which includes seven family members. To date four GIRK subunits, designated GIRK1-4 (also designated Kir3.1-4), have been identified in mammals, and GIRK5 has been found in Xenopus oocytes. GIRK channels exist in vivo both as homotetramers and heterotetramers. GIRK channels are modulated by G-proteins, they are also modulated by phosphatidylinositol 4,5-bisphosphate, intracellular sodium, ethanol and mechanical stretch. GIRK1, 2 and 3 are highly abundant in brain. In general, neuronal GIRK channels are involved in the regulation of the excitability of neurons and may contribute to the resting potential.Synonyms: BIR1, G protein-activated inward rectifier potassium channel 2, GIRK2, Inward rectifier K(+) channel Kir3.2, KATP-2, KATP2, KCNJ6, KCNJ7, Potassium channel, inwardly rectifying subfamily J member 6

ID gène: 3763

NCBI Accession: NP_002231

UniProt: P48051