AKR1B10 anticorps (C-Term)

N° du produit ABIN374920

Détail du produit anti-AKR1B10 anticorps

Antigène: AKR1B10 (Aldo-Keto Reductase Family 1, Member B10 (Aldose Reductase) (AKR1B10))

Épitope: C-Term

Reactivité: Humain

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp AKR1B10 est non-conjugé

Application: Western Blotting (WB)

Specificité: This antibody reacts to AKR1B10.

Purification: Affinity chromatography

Immunogène: Peptide with sequence C-QSSHLEDYPFDAE, from the C Terminus of the protein sequence

Information d'application

Indications d'application: Peptide ELISA: 1/8000. Western Blot: 0.03 - 0.1 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0,5 mg/mL

Buffer: Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Références pour anticorps anti-AKR1B10 (ABIN374920)

Díez-Dacal, Gayarre, Gharbi, Timms, Coderch, Gago, Pérez-Sala: "Identification of aldo-keto reductase AKR1B10 as a selective target for modification and inhibition by prostaglandin A(1): implications for antitumoral activity." dans: Cancer research, Vol. 71, Issue 12, pp. 4161-71, (2011) (PubMed).

Détails sur AKR1B10

Antigène: AKR1B10 (Aldo-Keto Reductase Family 1, Member B10 (Aldose Reductase) (AKR1B10))

Autre désignation: AKR1B10 (AKR1B10 Produits)

Synonymes: anticorps AKR1B11, anticorps AKR1B12, anticorps ALDRLn, anticorps ARL-1, anticorps ARL1, anticorps HIS, anticorps HSI, anticorps 2310005E10Rik, anticorps Akr1b16, anticorps AKR, anticorps AKR1B10, anticorps Akr1b10, anticorps aldo-keto reductase family 1 member B10, anticorps aldo-keto reductase family 1, member B10 (aldose reductase), anticorps aldo-keto reductase family 1 member B10-like 2, anticorps AKR1B10, anticorps Akr1b10, anticorps AKR1B10L2, anticorps LOC100585902, anticorps LOC100723118, anticorps LOC101107697

Sujet: ARK1B10 is a NADPH dependant enzyme with an ability to efficiently reduce aliphatic and aromatic aldehydes. A 316 A.A protein, AKR1B10 is a highly efficient retinal reductase constituting the first cytosolic NADP (H) dependent retinal reductase described in humans and is characterized by the presence of a novel NADP binding motif. Due to its ability to convert glucose to sorbitol, AKR1B10 may have a role in development of secondary diabetic complications. It is abundantly expressed in adrenal gland, small intestine and colon, with lower levels in liver, thymus, prostate, testis, and skeletal muscle and its levels are up regulated in certain cancers such as hepatocellular carcinoma.Synonyms: AKR1B11, ARL-1, Aldo-keto reductase family 1 member B10, Aldose reductase-like, Aldose reductase-related protein, Small intestine reductase

ID gène: 57016, 9606

UniProt: O60218