BAG4 anticorps (Internal Region)

N° du produit ABIN375054

Cet anticorps anti-BAG4 est un anticorps Chèvre Polyclonal détectant BAG4 dans WB. Adapté pour Humain.

Aperçu rapide pour BAG4 anticorps (Internal Region) (ABIN375054)

Antigène: BAG4 (BCL2-Associated Athanogene 4 (BAG4))

Reactivité: Humain

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp BAG4 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-BAG4 anticorps

Épitope: Internal Region

Specificité: This antibody reacts to SODD.

Purification: Affinity chromatography

Immunogène: Peptide with sequence C-GNATSDHPNNQDQSS, from the internal region of the protein sequence

Information d'application

Indications d'application: Peptide ELISA: 1/8000. Western Blot: 0.3 - 1 μg/mL.

Restrictions: For Research Use only

Stockage

Concentration: 0,5 mg/mL

Buffer: Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur BAG4

Antigène: BAG4 (BCL2-Associated Athanogene 4 (BAG4))

Autre désignation: BAG4

Sujet: Several cell surface receptors that are involved in apoptosis contain intracellular death domains and are capable of triggering apoptosis when activated by their respective ligands. Due to presence of these death domains and presence of various stimuli in the serum as well as overexpression leading to receptor oligomerization, which leads to constitutive activation of the apoptotic pathway, it has been extremely difficult to generate permanent cell lines overexpressing specific receptors in culture. However, in normal states, this death domain activity is silenced presumably due to presence of other cellular factors. Recently, a DR3 associated protein has been isolated by yeast two-hybrid interaction assays. This cDNA encoding a 457-amino acid protein has been named as SODD (Silencer of Death Domain). SODD also associates with the intracellular domains of TNF-R1, but not with those of TNF-R2, Fas, DR4, or DR5. SODD overexpression suppressed the TNF induced cell death as well as NF-kB activation. SODD may act as a negative regulatory protein that is normally associated with death domain of TNF-R1 and probably inhibit self-oligomerization properties of death domain and maintain TNF-R1 in an inactive, monomeric state. SODD (Silencer of Death Domain) is an important regulator of TNF induced apoptotic pathway. It associates with TNF-R1 to prevent constitutive activation of the signaling events downstream. It dissociates from the TNF-R1 after TNF binds TNF-R1 to allow the activation of apoptotic pathway. It is expressed ubiquitously in human tissues.Synonyms: BAG family molecular chaperone regulator 4, BAG-4, Bcl-2-associated athanogene 4, SODD, Silencer of death domains

ID gène: 9530, 9606

UniProt: O95429

Pathways: Regulation of Actin Filament Polymerization