BAG4 anticorps (Internal Region)
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- Antigène Voir toutes BAG4 Anticorps
- BAG4 (BCL2-Associated Athanogene 4 (BAG4))
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Épitope
- Internal Region
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Reactivité
- Humain
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Hôte
- Chèvre
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp BAG4 est non-conjugé
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Application
- Western Blotting (WB)
- Specificité
- This antibody reacts to SODD.
- Purification
- Affinity chromatography
- Immunogène
- Peptide with sequence C-GNATSDHPNNQDQSS, from the internal region of the protein sequence
- Top Product
- Discover our top product BAG4 Anticorps primaire
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- Indications d'application
- Peptide ELISA: 1/8000. Western Blot: 0.3 - 1 μg/mL.
- Restrictions
- For Research Use only
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- Concentration
- 0,5 mg/mL
- Buffer
- Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Antigène
- BAG4 (BCL2-Associated Athanogene 4 (BAG4))
- Autre désignation
- BAG4 (BAG4 Produits)
- Synonymes
- anticorps BAG-4, anticorps SODD, anticorps BAG4, anticorps fd20a04, anticorps wu:fd20a04, anticorps si:dkey-220o5.3, anticorps 2410112I15Rik, anticorps ATBAG4, anticorps BCL-2-associated athanogene 4, anticorps BCL2 associated athanogene 4, anticorps BCL2-associated athanogene 4, anticorps BCL-2-associated athanogene 4, anticorps BAG4, anticorps Bag4, anticorps bag4
- Sujet
- Several cell surface receptors that are involved in apoptosis contain intracellular death domains and are capable of triggering apoptosis when activated by their respective ligands. Due to presence of these death domains and presence of various stimuli in the serum as well as overexpression leading to receptor oligomerization, which leads to constitutive activation of the apoptotic pathway, it has been extremely difficult to generate permanent cell lines overexpressing specific receptors in culture. However, in normal states, this death domain activity is silenced presumably due to presence of other cellular factors. Recently, a DR3 associated protein has been isolated by yeast two-hybrid interaction assays. This cDNA encoding a 457-amino acid protein has been named as SODD (Silencer of Death Domain). SODD also associates with the intracellular domains of TNF-R1, but not with those of TNF-R2, Fas, DR4, or DR5. SODD overexpression suppressed the TNF induced cell death as well as NF-kB activation. SODD may act as a negative regulatory protein that is normally associated with death domain of TNF-R1 and probably inhibit self-oligomerization properties of death domain and maintain TNF-R1 in an inactive, monomeric state. SODD (Silencer of Death Domain) is an important regulator of TNF induced apoptotic pathway. It associates with TNF-R1 to prevent constitutive activation of the signaling events downstream. It dissociates from the TNF-R1 after TNF binds TNF-R1 to allow the activation of apoptotic pathway. It is expressed ubiquitously in human tissues.Synonyms: BAG family molecular chaperone regulator 4, BAG-4, Bcl-2-associated athanogene 4, SODD, Silencer of death domains
- ID gène
- 9530, 9606
- UniProt
- O95429
- Pathways
- Regulation of Actin Filament Polymerization
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