MBNL1 anticorps (C-Term)

N° du produit ABIN375072

Cet anticorps anti-MBNL1 Polyclonal Chèvre (ABIN375072) détecte spécifiquement MBNL1 dans WB. L’anticorps est réactif avec des échantillons de Humain, Souris, Rat, Chien et Boeuf (Vache).

Aperçu rapide pour MBNL1 anticorps (C-Term) (ABIN375072)

Antigène: MBNL1 (Muscleblind-like Protein 1 (MBNL1))

Reactivité: Humain, Souris, Rat, Chien, Boeuf (Vache)

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp MBNL1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-MBNL1 anticorps

Épitope: C-Term

Specificité: This antibody reacts to MBNL1.

Réactivité croisée (Details): Species reactivity (expected):Mouse, Rat, Canine, Bovine.
Species reactivity (tested):Human.

Purification: Affinity chromatography

Immunogène: Peptide with sequence C-SAEHLTSHKYVTQ, from the C Terminus of the protein sequence

Information d'application

Indications d'application: Peptide ELISA: 1/4000. Western Blot: 1 - 3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0,5 mg/mL

Buffer: Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur MBNL1

Antigène: MBNL1 (Muscleblind-like Protein 1 (MBNL1))

Autre désignation: MBNL1

Sujet: Muscleblind 1 (MBNL1) binds to the CUG triplet expansion in dsRNA. It appears to play a role in RNA splicing. Several important human diseases are associated with expansion of polynucleotide sequences, in most cases trinucleotide repeats. Myotonic dystrophy (DM1) is one of these diseases, and is associated with increases in the number of CTG repeats in the 3' UTR of the gene encoding myotonin (a.k.a. DM Kinase, DMK or myotonin-Protein Kinase), a ser/thr kinase expressed specifically in muscle. Mammalian genomes contain three muscleblind-like proteins, generally referred to as MBNL1, MBNL2 and MBNL3, and all three were found to associate with long double stranded CUG RNA repeats, thus being triplet repeat expansion dsRNA-binding proteins.Synonyms: EXP, Muscleblind-like protein 1

ID gène: 4154, 9606

UniProt: Q9NR56

Pathways: Ribonucleoprotein Complex Subunit Organization