HNF1B anticorps (Internal Region)

N° du produit ABIN375249

Cet anticorps anti-HNF1B Polyclonal Chèvre (ABIN375249) détecte spécifiquement HNF1B dans WB, IF et EIA. L’anticorps est réactif avec des échantillons de Humain, Souris, Rat, Poisson zèbre (Danio rerio), Chien, Boeuf (Vache) et Porc.

Aperçu rapide pour HNF1B anticorps (Internal Region) (ABIN375249)

Antigène: HNF1B (HNF1 Homeobox B (HNF1B))

Reactivité: Humain, Souris, Rat, Poisson zèbre (Danio rerio), Chien, Boeuf (Vache), Porc

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp HNF1B est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Détail du produit anti-HNF1B anticorps

Épitope: Internal Region

Séquence: C-QAYDRQKNPS KEER

Specificité: This antibody is expected to recognize both reported isoforms (NP_000449.1 and NP_001159395.1).

Réactivité croisée (Details): Species reactivity (expected):Mouse, Rat, Canine, Pig, Cow, Zebrafish.
Species reactivity (tested):Human.

Purification: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide

Immunogène: Peptide with sequence from the internal region of the protein according to NP_000449.1, NP_001159395.1. Genename: HNF1B

Information d'application

Indications d'application: Peptide ELISA: 1/64000. Western Blot: 0.1 - 0.3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur HNF1B

Antigène: HNF1B (HNF1 Homeobox B (HNF1B))

Autre désignation: HNF1 beta / TCF2

Sujet: TCF2 encodes transcription factor 2, a liver specific factor of the homeobox containing basic helix turn helix family. The TCF2 protein is believed to form heterodimers with another liver specific member of this transcription factor family, TCF1, depending on the TCF2 isoform, the result may be to activate or inhibit transcription of target genes. A mutation of TCF2 that disrupts normal function has been identified as the cause of MODY5 (Maturity Onset of Diabetes, Type 5). A third human transcript variant is believed to exist based on such a variant in the rat. However, to date such an mRNA species has not been isolated. TCF2 probably binds to the inverted palindrome 5' GTTAATNATTAAC 3'.Synonyms: HNF-1-beta, HNF-1B, Hepatocyte nuclear factor 1-beta, LFB3, TCF-2, Transcription factor 2, Variant hepatic nuclear factor 1, vHNF1

ID gène: 6928

NCBI Accession: NP_000449

UniProt: P35680

Pathways: Hormone Transport, Stem Cell Maintenance, Tube Formation