ICAM1 anticorps

N° du produit ABIN375585

Cet anticorps anti-ICAM1 est un anticorps Souris Monoclonal détectant ICAM1 dans FACS. Adapté pour Humain.

Aperçu rapide pour ICAM1 anticorps (ABIN375585)

Antigène: ICAM1 (Intercellular Adhesion Molecule 1 (ICAM1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ICAM1 est non-conjugé

Application: Flow Cytometry (FACS)

Clone: 15-2

Détail du produit anti-ICAM1 anticorps

Specificité: Human/Porcine CD54, Mr 90 kDa

Attributs du produit: Mouse Anti-Human CD54-UNLB

Purification: Purified

Immunogène: Rheumatoid synovial cells and human monocytes

Isotype: IgG1

Information d'application

Indications d'application:

• Applications: FC - Quality tested , IHC-FS - Reported in literature , ICC - Reported in literature , IP - Reported in literature , WB - Reported in literature , Block - Reported in literature , Neut - Reported in literature , ELISA - Reported in literature
• Working Dilutions: Flow Cytometry Purified (UNLB) antibody 1 g/106 cells FITC, BIOT, PE, and APC conjugates 10 L/106 cells For flow cytometry, the suggested use of these reagents is in a final volume of 100 L

Commentaires:

Blocking Studies

Volume d'échantillon: 1 mL

Restrictions: For Research Use only

Stockage

Concentration: 0.1 mg/mL

Buffer: 0.1 mg of purified immunoglobulin in 1.0 mL of borate buffered saline,  pH 8.2. No preservatives or amine-containing buffer salts added

Agent conservateur: Without preservative

Conseil sur la manipulation: Each reagent is stable for the period shown on the bottle label if stored as directed.

Stock: 4 °C

Stockage commentaire: Store at 2-8°C

Détails sur ICAM1

Antigène: ICAM1 (Intercellular Adhesion Molecule 1 (ICAM1))

Autre désignation: CD54

Sujet: CD54, also known as intercellular cell adhesion molecule-1 (ICAM-1), is a 90-110 kDa type I transmembrane glycoprotein and a member of the immunoglobulin superfamily. It exhibits a wide tissue distribution, being expressed on both hematopoietic and non-hematopoietic cells. ICAM-1 expression on leukocytes is low but is rapidly upregulated upon activation. Expression on endothelium and other non-hematopoietic cells is strongly upregulated by inflammatory mediators. The ligands of ICAM-1 are CD11a/LFA-1 α and CD11b/Mac-1 α. Endothelial CD54 contributes to the extravasation of leukocytes from blood vessels, particularly in areas of inflammation. CD54 on antigen-presenting cells (APC) contributes to antigen-specific T cell activation, presumably by enhancing interactions between T cells and APC.

Pathways: Cellular Response to Molecule of Bacterial Origin, Regulation of Actin Filament Polymerization, Carbohydrate Homeostasis, Regulation of Leukocyte Mediated Immunity, Thromboxane A2 Receptor Signaling