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JMJD4 anticorps (N-Term)

JMJD4 Reactivité: Humain WB Hôte: Lapin Polyclonal RB10799 unconjugated
N° du produit ABIN387874
  • Antigène Tous les produits JMJD4
    JMJD4 (Jumonji Domain Containing 4 (JMJD4))
    Épitope
    • 8
    • 7
    • 6
    • 3
    • 1
    • 1
    • 1
    AA 1-30, N-Term
    Reactivité
    • 26
    • 12
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 26
    Lapin
    Clonalité
    • 26
    Polyclonal
    Conjugué
    • 16
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp JMJD4 est non-conjugé
    Application
    • 26
    • 15
    • 8
    • 4
    • 3
    • 1
    Western Blotting (WB)
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogène
    This JMJD4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human JMJD4.
    Clone
    RB10799
    Isotype
    Ig Fraction
  • Indications d'application
    WB: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Date de péremption
    6 months
  • Antigène
    JMJD4 (Jumonji Domain Containing 4 (JMJD4))
    Autre désignation
    JMJD4 (JMJD4 Produits)
    Synonymes
    anticorps JMJD4, anticorps 6430559I23, anticorps RGD1307186, anticorps jumonji domain containing 4, anticorps jumonji domain containing 4 L homeolog, anticorps JMJD4, anticorps jmjd4.L, anticorps Jmjd4
    Sujet
    Covalent modification of histones plays critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones. A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes have been identified that perform this specific function. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2CH3K9 (both of which demethylate histone 3 at lysine 9). Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed.
    Poids moléculaire
    52493
    ID gène
    65094
    NCBI Accession
    NP_001154937, NP_075383
    UniProt
    Q9H9V9
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