HDAC6 anticorps (C-Term)

N° du produit ABIN387955

Cet anticorps Lapin Polyclonal détecte spécifiquement HDAC6 dans WB et IHC (p). Il présente une réactivité envers Humain et a été mentionné dans 3+ publications.

Aperçu rapide pour HDAC6 anticorps (C-Term) (ABIN387955)

Antigène: HDAC6 (Histone Deacetylase 6 (HDAC6))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HDAC6 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB5653

Détail du produit anti-HDAC6 anticorps

Épitope: AA 1182-1215, C-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This HDAC6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1182-1215 amino acids from the C-terminal region of human HDAC6.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:2000. IHC-P: 1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-HDAC6 (ABIN387955)

Ran, Yang, Li, Liu, Zhou: "Deacetylation of ?-tubulin and cortactin is required for HDAC6 to trigger ciliary disassembly." dans: Scientific reports, Vol. 5, pp. 12917, (2015) (PubMed).

Yu, Diao, Wang, Lin, Yu, Lu, Xu, Li, Shi, Zhao, Zhou, Zhang: "Acetylproteomic analysis reveals functional implications of lysine acetylation in human spermatozoa (sperm)." dans: Molecular & cellular proteomics : MCP, Vol. 14, Issue 4, pp. 1009-23, (2015) (PubMed).

Wang, Chen, Zhang, Zhang, Zhuo, Liu, Jiang, Zhang: "PCM1 recruits Plk1 to the pericentriolar matrix to promote primary cilia disassembly before mitotic entry." dans: Journal of cell science, Vol. 126, Issue Pt 6, pp. 1355-65, (2013) (PubMed).

Détails sur HDAC6

Antigène: HDAC6 (Histone Deacetylase 6 (HDAC6))

Autre désignation: HDAC6

Sujet: HDAC6 (histone deacetylase 6) is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. HDAC6 plays a central role in microtubule-dependent cell motility via deacetylation of tubulin, and has been shown to interact with HDAC11, SIRT2, and F-actin. HDAC6 is ubiquitinated, but its polyubiquitination however does not lead to degradation. HDAC is also a potential target of sumoylation.

Poids moléculaire: 131419

ID gène: 10013

NCBI Accession: NP_006035

UniProt: Q9UBN7

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling