ISG15 anticorps (N-Term)

N° du produit ABIN387983

Détail du produit anti-ISG15 anticorps

Antigène: ISG15 (ISG15 Ubiquitin-Like Modifier (ISG15))

Épitope: AA 31-61, N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ISG15 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This ISG15 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 31-61 amino acids from the N-terminal region of human ISG15.

Clone: RB02791

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-ISG15 (ABIN387983)

Cheriyamundath, Basu, Haase, Doernberg, Gavert, Brabletz, Ben-Zeev: "ISG15 induction is required during L1-mediated colon cancer progression and metastasis." dans: Oncotarget, Vol. 10, Issue 67, pp. 7122-7131, (2019) (PubMed).

Speer, Li, Buta, Payelle-Brogard, Qian, Vigant, Rubino, Gardner, Wedeking, Hermann, Duehr, Sanal, Tezcan, Mansouri, Tabarsi, Mansouri, Francois-Newton, Daussy, Rodriguez, Lenschow, Freiberg et al.: "ISG15 deficiency and increased viral resistance in humans but not mice. ..." dans: Nature communications, Vol. 7, pp. 11496, (2018) (PubMed).

Katzenell, Leib: "Herpes simplex virus and interferon signaling induce novel autophagic clusters in sensory neurons." dans: Journal of virology, (2016) (PubMed).

Huang, Bulavin: "Oncogene-mediated regulation of p53 ISGylation and functions." dans: Oncotarget, Vol. 5, Issue 14, pp. 5808-18, (2015) (PubMed).

Schanz, Baston-Büst, Heiss, Beyer, Krüssel, Hess: "Interferon stimulated gene 15 expression at the human embryo-maternal interface." dans: Archives of gynecology and obstetrics, Vol. 290, Issue 4, pp. 783-9, (2014) (PubMed).

Détails sur ISG15

Antigène: ISG15 (ISG15 Ubiquitin-Like Modifier (ISG15))

Autre désignation: ISG15 (ISG15 Produits)

Synonymes: anticorps G1P2, anticorps IFI15, anticorps IP17, anticorps UCRP, anticorps hUCRP, anticorps ISG15, anticorps g1p2, anticorps si:rp71-1c23.2, anticorps G1p2, anticorps IGI15, anticorps Irfp, anticorps ISG17, anticorps ISG17/UCRP, anticorps ISG15 ubiquitin-like modifier, anticorps ISG15, anticorps isg15, anticorps Isg15

Sujet: ISG15 is secreted from monocytes in response to type I interferons and causes natural killer (NK)-cell proliferation and an augmentation of non-MCH (major histocompatibility complex)-restricted cytotoxicity. Synthesis is stimulated by IFN-alpha or IFN-beta or IFN-omega , but not IFN-gamma . ISG15 expression is also induced by overexpression of interferon regulatory factors that participate in transcriptional regulation of IFN genes, and by influenza B virus. ISG15 is secreted also by cell lines of monocyte, T-lymphocyte, B-lymphocyte, human fibroblasts, and epithelial origins. The induction of terminal differentiation in human melanoma cells is associated with alterations in ISG15 expression. Enhancement of NK cell proliferation, augmentation of non-major histocompatibility complex-restricted cytotoxicity, and induction of IFN-gamma from T cells identify ISG15 as a member of the cytokine cascade and suggest that it may be responsible for amplifying and directing some of the immunomodulatory effects of IFN-alpha or IFN-beta. ISG15 has has also been shown to function intracellularly as a ubiquitin homolog.

Poids moléculaire: 17888

ID gène: 9636

NCBI Accession: NP_005092

UniProt: P05161