PRDM14 anticorps (N-Term)

N° du produit ABIN388018

Cet anticorps Lapin Polyclonal détecte spécifiquement PRDM14 dans WB, IF et IHC (p). Il présente une réactivité avec des échantillons de Humain. Il a été cité dans 4+ publications.

Aperçu rapide pour PRDM14 anticorps (N-Term) (ABIN388018)

Antigène: PRDM14 (PR Domain Containing 14 (PRDM14))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PRDM14 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB1405

Détail du produit anti-PRDM14 anticorps

Épitope: AA 1-30, N-Term

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This PRDM14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human PRDM14.

Isotype: Ig Fraction

Information d'application

Indications d'application: IF: 1:10~50. WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-PRDM14 (ABIN388018)

Sugawa, Araúzo-Bravo, Yoon, Kim, Aramaki, Wu, Stehling, Psathaki, Hübner, Schöler: "Human primordial germ cell commitment in vitro associates with a unique PRDM14 expression profile." dans: The EMBO journal, Vol. 34, Issue 8, pp. 1009-24, (2015) (PubMed).

Tsuneyoshi, Sumi, Onda, Nojima, Nakatsuji, Suemori: "PRDM14 suppresses expression of differentiation marker genes in human embryonic stem cells." dans: Biochemical and biophysical research communications, Vol. 367, Issue 4, pp. 899-905, (2008) (PubMed).

Watanabe, Toyota, Kondo, Suzuki, Imai, Ohe-Toyota, Maruyama, Nojima, Sasaki, Sekido, Hiratsuka, Shinomura, Imai, Itoh, Tokino: "PRDM5 identified as a target of epigenetic silencing in colorectal and gastric cancer." dans: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 13, Issue 16, pp. 4786-94, (2007) (PubMed).

Nishikawa, Toyota, Suzuki, Honma, Fujikane, Ohmura, Nishidate, Ohe-Toyota, Maruyama, Sonoda, Sasaki, Urano, Imai, Hirata, Tokino: "Gene amplification and overexpression of PRDM14 in breast cancers." dans: Cancer research, Vol. 67, Issue 20, pp. 9649-57, (2007) (PubMed).

Détails sur PRDM14

Antigène: PRDM14 (PR Domain Containing 14 (PRDM14))

Autre désignation: PRDM14 (PFM11)

Sujet: Similar to acetylation and phosphorylation, histone methylation at the N terminal tail has emerged as an important role in regulating chromatin dynamics and gene activity. Histone methylation occurs on arginine and lysine residues and is catalyzed by two families of proteins, the protein arginine methyltransferase family and the SET domain containing methyltransferase family. Five members have been identified in the arginine methyltransferase family. About 27 are grouped into the SET domain family, and another 17 make up the PR domain family that is related to the SET domain family. PRDM14 is part of a family of PR domain genes that are involved in tumorigenesis. It may function as a transcription factor.

Poids moléculaire: 64062

ID gène: 63978

NCBI Accession: NP_078780

UniProt: Q9GZV8