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SUMO4 anticorps (Mutant, Val55)

SUMO4 Reactivité: Humain WB, IHC (p) Hôte: Lapin Polyclonal RB7264 unconjugated
N° du produit ABIN388079
  • Antigène Voir toutes SUMO4 Anticorps
    SUMO4 (Small Ubiquitin Related Modifier 4 (SUMO4))
    Épitope
    • 8
    • 8
    • 6
    • 6
    • 6
    • 5
    • 3
    • 1
    • 1
    • 1
    • 1
    Mutant, Val55
    Reactivité
    • 54
    • 18
    • 18
    Humain
    Hôte
    • 51
    • 3
    Lapin
    Clonalité
    • 43
    • 11
    Polyclonal
    Conjugué
    • 25
    • 5
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp SUMO4 est non-conjugé
    Application
    • 38
    • 28
    • 25
    • 7
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogène
    This SUMO4 antibody is generated from rabbits immunized with a KLH conjugated peptide CEPRGLS(V)KQIRFRFG selected from human SUMO4. This antibody is affinity purified using peptides CEPRGLS(V)KQIRFRFG (positive selection) and CEPRGLS(M)KQIRFRFG (negative selection).
    Clone
    RB7264
    Isotype
    Ig Fraction
  • Indications d'application
    WB: 1:1000. WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100. IHC-P: 1:50~100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Date de péremption
    6 months
  • Antigène
    SUMO4 (Small Ubiquitin Related Modifier 4 (SUMO4))
    Autre désignation
    SUMO4 (SUMO4 Produits)
    Synonymes
    anticorps IDDM5, anticorps SMT3H4, anticorps SUMO-4, anticorps dJ281H8.4, anticorps small ubiquitin-like modifier 4, anticorps small ubiquitin-related modifier 4, anticorps SMT3 suppressor of mif two 3 homolog 4 (S. cerevisiae), anticorps SUMO4, anticorps sumo4
    Sujet
    SUMO4 is a member of the SUMO gene family. This family of small ubiquitin-related modifiers covalently modify target lysines in proteins and control the target proteins' subcellular localization, stability, or activity. Upon oxidative stress, SUMO4 conjugates to various anti-oxidant enzymes, chaperones, and stress defense proteins. This protein may also conjugate to NFKBIA, TFAP2A and FOS, negatively regulating their transcriptional activity, and to NR3C1, positively regulating its transcriptional activity. Covalent attachment to SUMO4 substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I. In contrast to SUMO1, SUMO2 and SUMO3, SUMO4 seems to be insensitive to sentrin-specific proteases due to the presence of Pro-90. This may impair processing to mature form and conjugation to substrates. SUMO4 is located in the cytoplasm and specifically modifies IKBA, leading to negative regulation of NF-kappa-B-dependent transcription of the IL12B gene. The M55V substitution has been associated with type I diabetes.
    Poids moléculaire
    10685
    ID gène
    387082
    NCBI Accession
    NP_001002255
    UniProt
    Q6EEV6
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