Pan SUMO (SUMO (pan)) anticorps

N° du produit ABIN388089

Cet anticorps anti- est un anticorps Lapin Polyclonal détectant dans WB, IF et IHC (p). Adapté pour Humain et Rat. Ce Primary Antibody a été cité dans 3+ publications.

Aperçu rapide pour Pan SUMO (SUMO (pan)) anticorps (ABIN388089)

Antigène: Pan SUMO (SUMO (pan))

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Inconjugué

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB04602

Détail du produit

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: "This Pan SUMO antibody recognizes SUMO2 and SUMO3. This antibody is generated from rabbits immunized with a recombinant protein encoding full length human SUMO3."

Isotype: Ig Fraction

Information d'application

Indications d'application: IF: 1:10~50. WB: 1:1000. IHC-P: 1:100. IHC-P: 1:50~100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Référence

Dunphy, Luo, McBride: "Ehrlichia chaffeensis exploits host SUMOylation pathways to mediate effector-host interactions and promote intracellular survival." dans: Infection and immunity, Vol. 82, Issue 10, pp. 4154-68, (2014) (PubMed).

Sun, Hunter: "Poly-small ubiquitin-like modifier (PolySUMO)-binding proteins identified through a string search." dans: The Journal of biological chemistry, Vol. 287, Issue 50, pp. 42071-83, (2012) (PubMed).

Lutz, Wolters-Eisfeld, Joshi, Djogo, Jakovcevski, Schachner, Kleene: "Generation and nuclear translocation of sumoylated transmembrane fragment of cell adhesion molecule L1." dans: The Journal of biological chemistry, Vol. 287, Issue 21, pp. 17161-75, (2012) (PubMed).

Détail du antigène

Antigène: Pan SUMO (SUMO (pan))

Autre désignation: Pan SUMO

Sujet: Covalent modification of target lysines by SUMO (small ubiquitin-like modifier) modulates processes such as protein localization, transcription, nuclear transport, mitosis, DNA replication and repair, signal transduction, and viral reproduction. SUMO does not seem to be involved in protein degradation and may in fact function as an antagonist of ubiquitin in the degradation process. The SUMO family consists of SUMO1 and closely related homologs SUMO2, SUMO3, and SUMO4. Sumoylation has been shown to regulate a wide range of proteins, including MDM2, PIAS, PML, RanGAP1, RanBP2, p53, p73, HIPK2, TEL, c-Jun, Fas, Daxx, TNFRI, Topo-I, Topo-II, PARK2, WRN, Sp100, IkB-alpha, Androgen receptor (AR), GLUT1/4, CaMK, DNMT3B, TDG, HIF1A, CHD3, EXOSC9, RAD51, and viral targets such as CMV-IE1/2, EBV-BZLF1, and HPV/BPV-E1.

Poids moléculaire: 11637

ID gène: 6612

NCBI Accession: NP_008867

UniProt: P55854