ATG12 anticorps (N-Term)

N° du produit ABIN388536

Cet anticorps anti-ATG12 est un anticorps Lapin Polyclonal détectant ATG12 dans WB, IF et IHC (p). Adapté pour Humain. Ce Primary Antibody a été cité dans 5+ publications.

Aperçu rapide pour ATG12 anticorps (N-Term) (ABIN388536)

Antigène: ATG12 (Autophagy Related 12 (ATG12))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ATG12 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB7475

Détail du produit anti-ATG12 anticorps

Épitope: AA 1-30, N-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This ATG12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human ATG12.

Isotype: Ig Fraction

Information d'application

Indications d'application: IF: 1:200. WB: 1:2000. IHC-P: 1:50~100. IHC-P: 1:50~100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-ATG12 (ABIN388536)

Yang, Zhao, Mei, Jiang, Geng, Li, Yao, Liu, Kong, Cao: "HMGA2 plays an important role in Cr (VI)-induced autophagy." dans: International journal of cancer, Vol. 141, Issue 5, pp. 986-997, (2017) (PubMed).

Chen, Cao, Zhou, Liu, Che, Mizumura, Li, Choi, Shen: "Interaction of caveolin-1 with ATG12-ATG5 system suppresses autophagy in lung epithelial cells." dans: American journal of physiology. Lung cellular and molecular physiology, Vol. 306, Issue 11, pp. L1016-25, (2014) (PubMed).

Sanchez, Penfornis, Oskowitz, Boonjindasup, Cai, Dhule, Rowan, Kelekar, Krause, Pochampally: "Activation of autophagy in mesenchymal stem cells provides tumor stromal support." dans: Carcinogenesis, Vol. 32, Issue 7, pp. 964-72, (2011) (PubMed).

Yee, Wilkinson, James, Ryan, Vousden: "PUMA- and Bax-induced autophagy contributes to apoptosis." dans: Cell death and differentiation, Vol. 16, Issue 8, pp. 1135-45, (2009) (PubMed).

Harada, Willison, Sakakibara, Miyamoto, Fujita, Taniguchi: "Absence of the type I IFN system in EC cells: transcriptional activator (IRF-1) and repressor (IRF-2) genes are developmentally regulated." dans: Cell, Vol. 63, Issue 2, pp. 303-12, (1990) (PubMed).

Détails sur ATG12

Antigène: ATG12 (Autophagy Related 12 (ATG12))

Autre désignation: ATG12

Sujet: Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). APG12L is the human homolog of yeast APG12, a ubiquitin-activating enzyme E1-like protein essential for the conjugation system that mediates membrane fusion in autophagy.

Poids moléculaire: 15113

ID gène: 9140

NCBI Accession: NP_001264712, NP_004698

UniProt: O94817

Pathways: Autophagy