Beclin 1 anticorps (AA 210-239)

N° du produit ABIN388546

Détail du produit anti-Beclin 1 anticorps

Antigène: Beclin 1 (BECN1) (Beclin 1, Autophagy Related (BECN1))

Épitope: AA 210-239

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Beclin 1 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Homologie: B, Pig, Rat

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This Beclin 1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 210-239 amino acids from human Beclin 1.

Clone: RB7463

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:4000. WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100. FC: 1:10~50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-Beclin 1 (ABIN388546)

Pla, Pascual, Guerri: "Autophagy Constitutes a Protective Mechanism against Ethanol Toxicity in Mouse Astrocytes and Neurons." dans: PLoS ONE, Vol. 11, Issue 4, pp. e0153097, (2016) (PubMed).

Li, Xiong, Shi, Xiao, Qi, Meng: "IKKβ/NFκBp65 activated by interleukin-13 targets the autophagy-related genes LC3B and beclin 1 in fibroblasts co-cultured with breast cancer cells." dans: Experimental and therapeutic medicine, Vol. 11, Issue 4, pp. 1259-1264, (2016) (PubMed).

Jia, Jin, Xiao, Dong, Wang, Fan, Xu, Meng, Li, Lv: "Lipoxin A4 methyl ester alleviates vascular cognition impairment by regulating the expression of proteins related to autophagy and ER stress in the rat hippocampus." dans: Cellular & molecular biology letters, Vol. 20, Issue 3, pp. 475-87, (2015) (PubMed).

Liu, He, von Rütte, Yousefi, Hunger, Simon: "Down-regulation of autophagy-related protein 5 (ATG5) contributes to the pathogenesis of early-stage cutaneous melanoma." dans: Science translational medicine, Vol. 5, Issue 202, pp. 202ra123, (2013) (PubMed).

Dhule, Penfornis, Frazier, Walker, Feldman, Tan, He, Alb, John, Pochampally: "Curcumin-loaded ?-cyclodextrin liposomal nanoparticles as delivery vehicles for osteosarcoma." dans: Nanomedicine : nanotechnology, biology, and medicine, Vol. 8, Issue 4, pp. 440-51, (2012) (PubMed).

Wang, Whiteman, Lian, Wang, Singh, Huang, Denmark: "A non-canonical MEK/ERK signaling pathway regulates autophagy via regulating Beclin 1." dans: The Journal of biological chemistry, Vol. 284, Issue 32, pp. 21412-24, (2009) (PubMed).

Détails sur Beclin 1

Antigène: Beclin 1 (BECN1) (Beclin 1, Autophagy Related (BECN1))

Autre désignation: Beclin 1 (BECN1 Produits)

Synonymes: anticorps beclin-1, anticorps atg6, anticorps vps30, anticorps beclin1, anticorps Beclin-1, anticorps becn1, anticorps zgc:73097, anticorps ATG6, anticorps VPS30, anticorps 4921513J16Rik, anticorps 5430417M23Rik, anticorps Atg6, anticorps beclin 1, anticorps beclin 1, autophagy related, anticorps beclin 1 protein, anticorps beclin-1, anticorps beclin family protein, anticorps beclin 1, autophagy related L homeolog, anticorps BECN1, anticorps becn1, anticorps atg6, anticorps CpipJ_CPIJ011087, anticorps PTRG_07825, anticorps SJAG_01876, anticorps Becn1, anticorps becn1.L

Sujet: Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). Beclin 1 plays a role in two fundamentally important cell biological pathways: autophagy and apoptosis. Beclin 1 is thought to function as a VPS and autophagy protein as part of a complex with Class III PI3 kinase, Vps34.

Poids moléculaire: 51896

ID gène: 8678

NCBI Accession: NP_003757

UniProt: Q14457

Pathways: Autophagy