Isocitrate Dehydrogenase [NADP] (IDH3) (AA 317-346), (C-Term) anticorps

N° du produit ABIN388634

Il existe 1 publication pour ce produit. L’anticorps anti-Isocitrate Dehydrogenase [NADP] Polyclonal Lapin est utilisé pour la détection de Isocitrate Dehydrogenase [NADP] dans des échantillons de Humain. Il a été validé pour WB.

Aperçu rapide pour Isocitrate Dehydrogenase [NADP] (IDH3) (AA 317-346), (C-Term) anticorps (ABIN388634)

Antigène: Isocitrate Dehydrogenase [NADP] (IDH3)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Application: Western Blotting (WB)

Clone: RB8430

Détail du produit

Épitope: AA 317-346, C-Term

Homologie: B, Pr, M, Rat

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This Isocitrate dehydrogenase (IDH3) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 317-346 amino acids from the C-terminal region of human Isocitrate dehydrogenase (IDH3).

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Référence

Johnson, Kaplitt: "Novel mitochondrial substrates of omi indicate a new regulatory role in neurodegenerative disorders." dans: PLoS ONE, Vol. 4, Issue 9, pp. e7100, (2009) (PubMed).

Détail du antigène

Antigène: Isocitrate Dehydrogenase [NADP] (IDH3)

Sujet: Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein described here is the alpha subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase.

Poids moléculaire: 39592

ID gène: 3419

NCBI Accession: NP_005521

UniProt: P50213