USP12,USP46 (AA 315-345), (C-Term) anticorps

N° du produit ABIN388899

Cet anticorps anti-USP12,USP46 Polyclonal Lapin (Clone RB4300) (ABIN388899) détecte spécifiquement USP12,USP46 dans WB. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour USP12,USP46 (AA 315-345), (C-Term) anticorps (ABIN388899)

Antigène: USP12,USP46

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Inconjugué

Application: Western Blotting (WB)

Clone: RB4300

Détail du produit

Épitope: AA 315-345, C-Term

Homologie: X, B, Zf, M, Rat

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This USP12/USP46 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 315-345 amino acids from the C-terminal region of human USP12/USP46.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Détail du antigène

Antigène: USP12,USP46

Autre désignation: USP12/USP46

Sujet: Modification of target proteins by ubiquitin participates in a wide array of biological functions. Proteins destined for degradation or processing via the 26 S proteasome are coupled to multiple copies of ubiquitin. However, attachment of ubiquitin or ubiquitin-related molecules may also result in changes in subcellular distribution or modification of protein activity. An additional level of ubiquitin regulation, deubiquitination, is catalyzed by proteases called deubiquitinating enzymes, which fall into four distinct families. Ubiquitin C-terminal hydrolases, ubiquitin-specific processing proteases (USPs),1 OTU-domain ubiquitin-aldehyde-binding proteins, and Jab1/Pad1/MPN-domain-containing metallo-enzymes. Among these four families, USPs represent the most widespread and represented deubiquitinating enzymes across evolution. USPs tend to release ubiquitin from a conjugated protein. They display similar catalytic domains containing conserved Cys and His boxes but divergent N-terminal and occasionally C-terminal extensions, which are thought to function in substrate recognition, subcellular localization, and protein-protein interactions.

Poids moléculaire: 42858

ID gène: 219333

NCBI Accession: NP_872294

UniProt: O75317