Ataxin 3 anticorps (N-Term)

N° du produit ABIN388975

Cet anticorps Lapin Polyclonal détecte spécifiquement Ataxin 3 dans IHC (p). Il présente une réactivité envers Humain.

Aperçu rapide pour Ataxin 3 anticorps (N-Term) (ABIN388975)

Antigène: Ataxin 3 (ATXN3)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Ataxin 3 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB4606

Détail du produit anti-Ataxin 3 anticorps

Épitope: AA 29-59, N-Term

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This Ataxin3 (MJD) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 29-59 amino acids from the N-terminal region of human Ataxin3 (MJD).

Isotype: Ig Fraction

Information d'application

Indications d'application: IHC-P: 1:50~100. IHC-P: 1:50~100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Détails sur Ataxin 3

Antigène: Ataxin 3 (ATXN3)

Autre désignation: Ataxin3 (MJD)

Sujet: Machado-Joseph disease is an autosomal dominant neurologic disorder, and is now known to be the same as previously described spinocerebellar ataxia-3. MJD protein (Ataxin-3) contains (CAG)n repeats in the coding region, and the expansion of these repeats from the normal 13-36 to 68-79 is the cause of Machado-Joseph disease. There is a negative correlation between the age of onset and CAG repeat numbers. This protein interacts with key regulators (CBP, p300 and PCAF) of transcription and represses transcription, and also acts as a histone-binding protein that regulates transcription. MJD is a deubiquitinating enzyme.

Poids moléculaire: 41250

ID gène: 4287

NCBI Accession: NP_001121168, NP_001158252, NP_004984, NP_109376

UniProt: P54252