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FDFT1 anticorps (AA 140-170)

FDFT1 Reactivité: Humain WB, IHC (p) Hôte: Lapin Polyclonal RB4781-4782 unconjugated
N° du produit ABIN389052
  • Antigène Voir toutes FDFT1 Anticorps
    FDFT1 (Farnesyl-Diphosphate Farnesyltransferase 1 (FDFT1))
    Épitope
    • 9
    • 9
    • 8
    • 7
    • 6
    • 6
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 140-170
    Reactivité
    • 70
    • 28
    • 13
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Humain
    Hôte
    • 72
    • 5
    Lapin
    Clonalité
    • 71
    • 6
    Polyclonal
    Conjugué
    • 36
    • 10
    • 9
    • 6
    • 5
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp FDFT1 est non-conjugé
    Application
    • 64
    • 43
    • 33
    • 7
    • 6
    • 6
    • 5
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogène
    This FDFT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 140-170 amino acids from the Central region of human FDFT1.
    Clone
    RB4781-4782
    Isotype
    Ig Fraction
    Top Product
    Discover our top product FDFT1 Anticorps primaire
  • Indications d'application
    WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100. IHC-P: 1:50~100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Date de péremption
    6 months
  • Zhang, Dai, Wang: "5-Aza-2'-deoxycytidine induced growth inhibition of leukemia cells through modulating endogenous cholesterol biosynthesis." dans: Molecular & cellular proteomics : MCP, Vol. 11, Issue 7, pp. M111.016915, (2012) (PubMed).

    Hammer, Bien, Salazar, Steil, Scharf, Hildebrandt, Schroeder, Kroemer, Völker, Ritter: "Proteomic analysis of doxorubicin-induced changes in the proteome of HepG2cells combining 2-D DIGE and LC-MS/MS approaches." dans: Proteomics, Vol. 10, Issue 1, pp. 99-114, (2010) (PubMed).

    Størvold, Fleten, Olsen, Follestad, Krokan, Schønberg: "Docosahexaenoic acid activates some SREBP-2 targets independent of cholesterol and ER stress in SW620 colon cancer cells." dans: Lipids, Vol. 44, Issue 8, pp. 673-83, (2009) (PubMed).

  • Antigène
    FDFT1 (Farnesyl-Diphosphate Farnesyltransferase 1 (FDFT1))
    Autre désignation
    FDFT1 (FDFT1 Produits)
    Synonymes
    anticorps FDFT1, anticorps DKFZp459C1712, anticorps SQS, anticorps SS, anticorps DGPT, anticorps ERG9, anticorps fdft1, anticorps farnesyl-diphosphate farnesyltransferase 1, anticorps squalene synthase, anticorps farnesyl diphosphate farnesyl transferase 1, anticorps FDFT1, anticorps fdft1, anticorps LOC100560926, anticorps Fdft1
    Sujet
    FDFT1 catalyzes the first step in the cholesterol biosynthetic pathway, the conversion of trans-farnesyldiphosphate to squalene. The loss of promoter activity and response to sterols for FDFT1 is localized to a 69-bp section positioned 131 bp 5-prime to the transcription start site. Sequence analysis of this region shows that it contains a sterol regulatory element-1 (SRE1) previously identified in other sterol regulated genes and 2 putative NF1 binding sites.
    Poids moléculaire
    48115
    ID gène
    2222
    NCBI Accession
    NP_004453
    UniProt
    P37268
    Pathways
    Regulation of Lipid Metabolism by PPARalpha
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