PAPSS1 anticorps (C-Term)

N° du produit ABIN389138

L’anticorps Lapin Polyclonal anti-PAPSS1 a été validé pour WB. Il convient pour détecter PAPSS1 dans des échantillons de Humain. Il y a 1 publication disponible.

Aperçu rapide pour PAPSS1 anticorps (C-Term) (ABIN389138)

Antigène: PAPSS1 (3'-phosphoadenosine 5'-phosphosulfate Synthase 1 (PAPSS1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PAPSS1 est non-conjugé

Application: Western Blotting (WB)

Clone: RB5109

Détail du produit anti-PAPSS1 anticorps

Épitope: AA 592-624, C-Term

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This PAPSS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 592-624 amino acids from the C-terminal region of human PAPSS1.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-PAPSS1 (ABIN389138)

Bergelin, Blom, Heikkilä, Löf, Alam, Balthasar, Slotte, Hinkkanen, Törnquist: "Sphingosine kinase as an oncogene: autocrine sphingosine 1-phosphate modulates ML-1 thyroid carcinoma cell migration by a mechanism dependent on protein kinase C-alpha and ERK1/2." dans: Endocrinology, Vol. 150, Issue 5, pp. 2055-63, (2009) (PubMed).

Détails sur PAPSS1

Antigène: PAPSS1 (3'-phosphoadenosine 5'-phosphosulfate Synthase 1 (PAPSS1))

Autre désignation: PAPSS1

Sujet: Sulfotransferase (SULT) enzymes catalyze the sulfate conjugation of many drugs, xenobiotic compounds, hormones, and neurotransmitters. 3'-phosphoadenosine 5'-phosphosulfate (PAPS) synthase (PAPSS) catalyzes the biosynthesis of PAPS which serves as the universal sulfonate donor compound for all sulfotransferase reactions. In humans, PAPS is synthesized from adenosine 5-prime triphosphate (ATP) and inorganic sulfate by 2 isoforms, PAPSS1 and PAPSS2 (603005). Bifunctional PAPSS1 is comprised of an N-terminal APS kinase domain, and a C-terminal ATP sulfurylase domain. Full-length protein has significantly less APS kinase activity than the N-terminal fragment, suggesting that the C-terminal domain exerts a regulatory role on the N-terminal APS kinase activity. In humans there are two major isoforms: PAPSS1 and PAPSS2. In brain and skin PAPSS1 is the major isoform, whereas in liver, cartilage and adrenal glands PAPSS2 isoform expression dominates. The predicted 623-amino acid protein is 98 % identical to mouse PAPS synthase. The N-terminal 268-amino acid region of human PAPS synthase resembles APS kinases from other organisms and contains 3 conserved nucleotide-binding motifs.

Poids moléculaire: 70833

ID gène: 9061

NCBI Accession: NP_005434

UniProt: O43252

Pathways: Glycosaminoglycan Metabolic Process, Ribonucleoside Biosynthetic Process