SYK anticorps (pTyr525, pTyr526)

N° du produit ABIN389670

Cité dans 5 publications. Cet anticorps anti-SYK Polyclonal Lapin (Clone RB5669) (ABIN389670) détecte spécifiquement SYK dans WB et IHC (p). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour SYK anticorps (pTyr525, pTyr526) (ABIN389670)

Antigène: SYK (Spleen tyrosine Kinase (SYK))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SYK est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB5669

Détail du produit anti-SYK anticorps

Épitope: pTyr525, pTyr526

Homologie: M, Pig, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This Syk Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y525/526 of human Syk.

Isotype: IgG

Information d'application

Indications d'application: WB: 1:250. IHC-P: 1:50~100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid freeze-thaw cycles.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.

Date de péremption: 6 months

Références pour anticorps anti-SYK (ABIN389670)

Schweig, Yao, Beaulieu-Abdelahad, Ait-Ghezala, Mouzon, Crawford, Mullan, Paris: "Alzheimer's disease pathological lesions activate the spleen tyrosine kinase." dans: Acta neuropathologica communications, Vol. 5, Issue 1, pp. 69, (2018) (PubMed).

Köhler, Fuhr, Dinekov: "Distribution of spleen tyrosine kinase and tau phosphorylated at tyrosine 18 in a mouse model of tauopathy and in the human hippocampus." dans: Brain research, Vol. 1677, pp. 1-13, (2018) (PubMed).

Greenblatt, Park, Oh, Kim, Shin, Lee, Lee, Singh, Lee, Hu, Xiao, Charles, Penninger, Lotinun, Baron, Ghosh, Shim: "CHMP5 controls bone turnover rates by dampening NF-?B activity in osteoclasts." dans: The Journal of experimental medicine, Vol. 212, Issue 8, pp. 1283-301, (2015) (PubMed).

Nishikawa, Takahashi, Nakamori, Hosomi, Maruyama, Miyazaki, Izumi, Matsumoto: "The identification of raft-derived tau-associated vesicles that are incorporated into immature tangles and paired helical filaments." dans: Neuropathology and applied neurobiology, (2015) (PubMed).

Satoh, Tabunoki, Ishida, Yagishita, Jinnai, Futamura, Kobayashi, Toyoshima, Yoshioka, Enomoto, Arai, Saito, Arima: "Phosphorylated Syk expression is enhanced in Nasu-Hakola disease brains." dans: Neuropathology : official journal of the Japanese Society of Neuropathology, Vol. 32, Issue 2, pp. 149-57, (2012) (PubMed).

Détails sur SYK

Antigène: SYK (Spleen tyrosine Kinase (SYK))

Autre désignation: Syk

Sujet: Syk is a positive effector of BCR-stimulated responses. This protein couples the B-cell antigen receptor (BCR) to the mobilization of calcium ion either through a phosphoinositide 3-kinase-dependent pathway, when not phosphorylated on tyrosines of the linker region, or through a phospholipase C-gamma-dependent pathway, when phosphorylated on Tyr-342 and Tyr-346. Thus the differential phosphorylation of Syk can determine the pathway by which BCR is coupled to the regulation of intracellular calcium ion.

Poids moléculaire: 72066

ID gène: 6850

NCBI Accession: NP_001128524, NP_001167638, NP_001167639, NP_003168

UniProt: P43405

Pathways: Fc-epsilon Receptor Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Thromboxane A2 Receptor Signaling, BCR Signaling