LC3C anticorps (pSer12)

N° du produit ABIN389699

Il existe 6+ publications pour ce produit. L’anticorps anti-LC3C Polyclonal Lapin est utilisé pour la détection de LC3C dans des échantillons de Humain. Il a été validé pour WB et DB.

Aperçu rapide pour LC3C anticorps (pSer12) (ABIN389699)

Antigène: LC3C (MAP1LC3C) (Microtubule-Associated Protein 1 Light Chain 3 gamma (MAP1LC3C))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LC3C est non-conjugé

Application: Western Blotting (WB), Dot Blot (DB)

Clone: RB10838-RB16769

Détail du produit anti-LC3C anticorps

Épitope: pSer12

Homologie: Zf, B, M, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This LC3C Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S12 of human LC3C.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. WB: 1:1000. WB: 1:1000. WB: 1:1000. DB: 1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-LC3C (ABIN389699)

Tanaka, Koyama, Sakurai, Kamiyoshi, Ichikawa-Shindo, Kawate, Liu, Xian, Imai, Zhai, Hirabayashi, Owa, Yamauchi, Igarashi, Taniguchi, Shindo: "The endothelial adrenomedullin-RAMP2 system regulates vascular integrity and suppresses tumour metastasis." dans: Cardiovascular research, Vol. 111, Issue 4, pp. 398-409, (2017) (PubMed).

Xie, Kang, Tang: "Assessment of Posttranslational Modifications of ATG proteins." dans: Methods in enzymology, Vol. 587, pp. 171-188, (2017) (PubMed).

Li, Liu, Wang, Wang, Zhao, Su, Zhang, Zhang, Xu, Zhao, Miao: "Identification of a small molecule targeting annexin A7." dans: Biochimica et biophysica acta, Vol. 1833, Issue 9, pp. 2092-9, (2013) (PubMed).

Colecchia, Strambi, Sanzone, Iavarone, Rossi, DallArmi, Piccioni, Verrotti di Pianella, Chiariello: "MAPK15/ERK8 stimulates autophagy by interacting with LC3 and GABARAP proteins." dans: Autophagy, Vol. 8, Issue 12, pp. 1724-40, (2012) (PubMed).

Su, Chao, Huang, Weng, Jeng, Lai: "Rab5 and class III phosphoinositide 3-kinase Vps34 are involved in hepatitis C virus NS4B-induced autophagy." dans: Journal of virology, Vol. 85, Issue 20, pp. 10561-71, (2011) (PubMed).

Cherra, Kulich, Uechi, Balasubramani, Mountzouris, Day, Chu: "Regulation of the autophagy protein LC3 by phosphorylation." dans: The Journal of cell biology, Vol. 190, Issue 4, pp. 533-9, (2010) (PubMed).

Détails sur LC3C

Antigène: LC3C (MAP1LC3C) (Microtubule-Associated Protein 1 Light Chain 3 gamma (MAP1LC3C))

Autre désignation: LC3C

Sujet: MAP1A and MAP1B are microtubule-associated proteins which mediate the physical interactions between microtubules and components of the cytoskeleton. These proteins are involved in formation of autophagosomal vacuoles (autophagosomes). MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. MAP1LC3a is one of the light chain subunits and can associate with either MAP1A or MAP1B. The precursor molecule is cleaved by APG4B/ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II. Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole).

Poids moléculaire: 14272

ID gène: 84557

NCBI Accession: NP_115903, NP_852610

UniProt: Q9H492

Pathways: Autophagy