PIK3C3 anticorps (pSer676)

N° du produit ABIN389757

Cet anticorps anti-PIK3C3 Polyclonal Lapin (Clone RB11905) (ABIN389757) détecte spécifiquement PIK3C3 dans DB. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour PIK3C3 anticorps (pSer676) (ABIN389757)

Antigène: PIK3C3 (Phosphoinositide-3-Kinase, Class 3 (PIK3C3))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PIK3C3 est non-conjugé

Application: Dot Blot (DB)

Clone: RB11905

Détail du produit anti-PIK3C3 anticorps

Épitope: pSer676

Homologie: M, Pig, Rat, X

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This PI3KC3 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S676 of human PI3KC3.

Isotype: Ig Fraction

Information d'application

Indications d'application: DB: 1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Détails sur PIK3C3

Antigène: PIK3C3 (Phosphoinositide-3-Kinase, Class 3 (PIK3C3))

Autre désignation: PI3KC3

Sujet: PI3KC3 is a catalytic subunit of the PI3K complex involved in the transport of lysosomal enzyme precursors to lysosomes. This enzyme acts catalytically to convert 1-phosphatidyl-1D-myo-inositol to 1-phosphatidyl-1D-myo-inositol 3-phosphate. Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). The regulation of the Beclin 1-PI3KC3 complex lipid kinase activity is a critical element in the autophagy signaling pathway.

Poids moléculaire: 101549

ID gène: 5289

NCBI Accession: NP_002638

UniProt: Q8NEB9

Pathways: AMPK Signaling, Activation of Innate immune Response, Inositol Metabolic Process, Toll-Like Receptors Cascades, Autophagy