GREM1 anticorps (C-Term)

N° du produit ABIN390078

Cet anticorps anti-GREM1 est un anticorps Lapin Polyclonal détectant GREM1 dans WB. Adapté pour Humain et Souris. Ce Primary Antibody a été cité dans 9+ publications.

Aperçu rapide pour GREM1 anticorps (C-Term) (ABIN390078)

Antigène: GREM1 (Gremlin 1 (GREM1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GREM1 est non-conjugé

Application: Western Blotting (WB)

Clone: RB2060

Détail du produit anti-GREM1 anticorps

Épitope: AA 147-175, C-Term

Homologie: Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This GREMLIN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 147-175 amino acids from the C-terminal region of mouse GREMLIN.

Isotype: IgG

Information d'application

Indications d'application: WB: 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid freeze-thaw cycles.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.

Date de péremption: 6 months

Références pour anticorps anti-GREM1 (ABIN390078)

Staloch, Gao, Liu, Xu, Feng, Aronson, Falzon, Greeley, Rastellini, Chao, Hellmich, Cao, Ko: "Gremlin is a key pro-fibrogenic factor in chronic pancreatitis." dans: Journal of molecular medicine (Berlin, Germany), (2015) (PubMed).

Droguett, Krall, Burgos, Valderrama, Carpio, Ardiles, Rodriguez-Diez, Kerr, Walz, Ruiz-Ortega, Egido, Mezzano: "Tubular overexpression of gremlin induces renal damage susceptibility in mice." dans: PLoS ONE, Vol. 9, Issue 7, pp. e101879, (2014) (PubMed).

Ahn, Mercado, Laé, Ladanyi: "Identification of target genes of PAX3-FOXO1 in alveolar rhabdomyosarcoma." dans: Oncology reports, Vol. 30, Issue 2, pp. 968-78, (2013) (PubMed).

Gelse, Ekici, Cipa, Swoboda, Carl, Olk, Hennig, Klinger: "Molecular differentiation between osteophytic and articular cartilage--clues for a transient and permanent chondrocyte phenotype." dans: Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society, Vol. 20, Issue 2, pp. 162-71, (2012) (PubMed).

Jara, Chacón, Burgos, Droguett, Valdivieso, Ortiz, Troncoso, Mezzano: "Expression of gremlin, a bone morphogenetic protein antagonist,is associated with vascular calcification in uraemia." dans: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, Vol. 24, Issue 4, pp. 1121-9, (2009) (PubMed).

Carvajal, Droguett, Burgos, Aros, Ardiles, Flores, Carpio, Ruiz-Ortega, Egido, Mezzano: "Gremlin: a novel mediator of epithelial mesenchymal transition and fibrosis in chronic allograft nephropathy." dans: Transplantation proceedings, Vol. 40, Issue 3, pp. 734-9, (2008) (PubMed).

Mezzano, Droguett, Burgos, Aros, Ardiles, Flores, Carpio, Carvajal, Ruiz-Ortega, Egido: "Expression of gremlin, a bone morphogenetic protein antagonist, in glomerular crescents of pauci-immune glomerulonephritis." dans: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, Vol. 22, Issue 7, pp. 1882-90, (2007) (PubMed).

Wordinger, Fleenor, Hellberg, Pang, Tovar, Zode, Fuller, Clark: "Effects of TGF-beta2, BMP-4, and gremlin in the trabecular meshwork: implications for glaucoma." dans: Investigative ophthalmology & visual science, Vol. 48, Issue 3, pp. 1191-200, (2007) (PubMed).

Frank, Kho, Schatton, Murphy, Molloy, Zhan, Ramoni, Frank, Kohane, Gussoni: "Regulation of myogenic progenitor proliferation in human fetal skeletal muscle by BMP4 and its antagonist Gremlin." dans: The Journal of cell biology, Vol. 175, Issue 1, pp. 99-110, (2006) (PubMed).

Détails sur GREM1

Antigène: GREM1 (Gremlin 1 (GREM1))

Autre désignation: GREMLIN

Sujet: GREMLIN is a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth.

Poids moléculaire: 20710

ID gène: 23892

NCBI Accession: NP_035954

UniProt: O70326

Pathways: Regulation of Muscle Cell Differentiation, Tube Formation, Maintenance of Protein Location