EDG4 anticorps (N-Term)

N° du produit ABIN390085

Cet anticorps Lapin Polyclonal détecte spécifiquement EDG4 dans WB et IHC (p). Il présente une réactivité envers Humain et a été mentionné dans 5+ publications.

Aperçu rapide pour EDG4 anticorps (N-Term) (ABIN390085)

Antigène: EDG4 (LPAR2) (Lysophosphatidic Acid Receptor 2 (LPAR2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EDG4 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB1827

Détail du produit anti-EDG4 anticorps

Épitope: AA 3-32, N-Term

Homologie: Pr

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This EDG4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 3-32 amino acids from the N-terminal region of human EDG4.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-EDG4 (ABIN390085)

Yamauchi, Yamamura, Katase, Itadani, Okada, Kobiki, Nakamura, Yamaguchi, Kuribayashi: "Evaluation of pancreatic cancer cell migration with multiple parameters in vitro by using an optical real-time cell mobility assay device." dans: BMC cancer, Vol. 17, Issue 1, pp. 234, (2017) (PubMed).

Geng, Lan, Singha, Gilchrist, Weinreb, Violette, Weinberg, Saikumar, Venkatachalam: "Lysophosphatidic acid increases proximal tubule cell secretion of profibrotic cytokines PDGF-B and CTGF through LPA2- and G?q-mediated Rho and ?v?6 integrin-dependent activation of TGF-?." dans: The American journal of pathology, Vol. 181, Issue 4, pp. 1236-49, (2012) (PubMed).

Bernhart, Kollroser, Rechberger, Reicher, Heinemann, Schratl, Hallström, Wintersperger, Nusshold, DeVaney, Zorn-Pauly, Malli, Graier, Malle, Sattler: "Lysophosphatidic acid receptor activation affects the C13NJ microglia cell line proteome leading to alterations in glycolysis, motility, and cytoskeletal architecture." dans: Proteomics, Vol. 10, Issue 1, pp. 141-58, (2010) (PubMed).

Todorova, Fuentes, Soria, Nadal, Quesada: "Lysophosphatidic acid induces Ca2+ mobilization and c-Myc expression in mouse embryonic stem cells via the phospholipase C pathway." dans: Cellular signalling, Vol. 21, Issue 4, pp. 523-8, (2009) (PubMed).

Horak, Lee, Elkahloun, Boissan, Dumont, Maga, Arnaud-Dabernat, Palmieri, Stetler-Stevenson, Lacombe, Meltzer, Steeg: "Nm23-H1 suppresses tumor cell motility by down-regulating the lysophosphatidic acid receptor EDG2." dans: Cancer research, Vol. 67, Issue 15, pp. 7238-46, (2007) (PubMed).

Détails sur EDG4

Antigène: EDG4 (LPAR2) (Lysophosphatidic Acid Receptor 2 (LPAR2))

Autre désignation: EDG4

Sujet: EDG4 is a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca2+ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins.

Poids moléculaire: 39084

ID gène: 9170

NCBI Accession: NP_004711

UniProt: Q9HBW0