SIRT6 anticorps (C-Term)

N° du produit ABIN390181

Cet anticorps Lapin Polyclonal détecte spécifiquement SIRT6 dans WB et IHC (p). Il présente une réactivité envers Humain et Souris et a été mentionné dans 4+ publications.

Aperçu rapide pour SIRT6 anticorps (C-Term) (ABIN390181)

Antigène: SIRT6 (Sirtuin 6 (SIRT6))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SIRT6 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB2109

Détail du produit anti-SIRT6 anticorps

Épitope: AA 290-319, C-Term

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This SIRT6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 290-319 amino acids from the C-terminal region of human SIRT6.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. WB: 1:500. IHC-P: 1:50~100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid freeze-thaw cycles.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.

Date de péremption: 6 months

Références pour anticorps anti-SIRT6 (ABIN390181)

Li, Shi, Yang, Yan, Zhang, Yang, He, Li, Yi, Sun, Liang, Cheng, Shi, Shang, Yu: "SIRT7 is a histone desuccinylase that functionally links to chromatin compaction and genome stability." dans: Nature communications, Vol. 7, pp. 12235, (2018) (PubMed).

Wang, Zhang, Liang, Zhang, Xu, Zhang, Fuji, Mu, Li, Jiang, Ju, Wang: "Cyclic AMP Mimics the Anti-ageing Effects of Calorie Restriction by Up-Regulating Sirtuin." dans: Scientific reports, Vol. 5, pp. 12012, (2015) (PubMed).

Wu, Liu, Fu, Liu, Zhou: "Direct evidence of sirtuin downregulation in the liver of non-alcoholic fatty liver disease patients." dans: Annals of clinical and laboratory science, Vol. 44, Issue 4, pp. 410-8, (2014) (PubMed).

Alhazzazi, Kamarajan, Joo, Huang, Verdin, DSilva, Kapila: "Sirtuin-3 (SIRT3), a novel potential therapeutic target for oral cancer." dans: Cancer, Vol. 117, Issue 8, pp. 1670-8, (2011) (PubMed).

Détails sur SIRT6

Antigène: SIRT6 (Sirtuin 6 (SIRT6))

Autre désignation: SIRT6

Sujet: SIRT6 is a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined, however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity.

Poids moléculaire: 39119

ID gène: 51548

NCBI Accession: NP_001180214, NP_057623

UniProt: Q8N6T7