SIRT7 anticorps (C-Term)

N° du produit ABIN390182

L’anticorps Lapin Polyclonal anti-SIRT7 a été validé pour WB et IHC (p). Il convient pour détecter SIRT7 dans des échantillons de Humain. Il y a 3+ publications disponibles.

Aperçu rapide pour SIRT7 anticorps (C-Term) (ABIN390182)

Antigène: SIRT7 (Sirtuin 7 (SIRT7))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SIRT7 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB1973

Détail du produit anti-SIRT7 anticorps

Épitope: AA 331-360, C-Term

Homologie: B, M, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This SIRT7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 331-360 amino acids from the C-terminal region of human SIRT7.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. WB: 1:2000. IHC-P: 1:25

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-SIRT7 (ABIN390182)

Wang, Yi, Li, Cai, He, Ni, Zhou, Cheng, Jin, Fan, Qiu: "Down-regulation of sirtuin 3 is associated with poor prognosis in hepatocellular carcinoma after resection." dans: BMC cancer, Vol. 14, pp. 297, (2014) (PubMed).

Sestito, Madonna, Scarponi, Cianfarani, Failla, Cavani, Girolomoni, Albanesi: "STAT3-dependent effects of IL-22 in human keratinocytes are counterregulated by sirtuin 1 through a direct inhibition of STAT3 acetylation." dans: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 25, Issue 3, pp. 916-27, (2011) (PubMed).

Alhazzazi, Kamarajan, Joo, Huang, Verdin, DSilva, Kapila: "Sirtuin-3 (SIRT3), a novel potential therapeutic target for oral cancer." dans: Cancer, Vol. 117, Issue 8, pp. 1670-8, (2011) (PubMed).

Détails sur SIRT7

Antigène: SIRT7 (Sirtuin 7 (SIRT7))

Autre désignation: SIRT7

Sujet: SIRT7 is a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined, however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity.

Poids moléculaire: 44898

ID gène: 51547

NCBI Accession: NP_057622

UniProt: Q9NRC8