AGR2 anticorps (AA 95-124)

N° du produit ABIN390227

L’anticorps Lapin Polyclonal anti-AGR2 a été validé pour WB et IHC (p). Il convient pour détecter AGR2 dans des échantillons de Humain. Il y a 2+ publications disponibles.

Aperçu rapide pour AGR2 anticorps (AA 95-124) (ABIN390227)

Antigène: AGR2 (Anterior Gradient Homolog 2 (Xenopus Laevis) (AGR2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp AGR2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB13858

Détail du produit anti-AGR2 anticorps

Épitope: AA 95-124

Homologie: Zf, M

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This AGR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 95-124 amino acids from the Central region of human AGR2.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. WB: 1:1000. IHC-P: 1:10~50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-AGR2 (ABIN390227)

Guo, Chen, Zhu, Yu, Rong, Merugu, Mangukiya, Li: "A humanized monoclonal antibody targeting secreted anterior gradient 2 effectively inhibits the xenograft tumor growth." dans: Biochemical and biophysical research communications, Vol. 475, Issue 1, pp. 57-63, (2017) (PubMed).

Guo, Zhu, Yu, Merugu, Mangukiya, Smith, Li, Zhang, Negi, Rong, Cheng, Wu, Li: "Tumor-secreted anterior gradient-2 binds to VEGF and FGF2 and enhances their activities by promoting their homodimerization." dans: Oncogene, Vol. 36, Issue 36, pp. 5098-5109, (2017) (PubMed).

Détails sur AGR2

Antigène: AGR2 (Anterior Gradient Homolog 2 (Xenopus Laevis) (AGR2))

Autre désignation: Anterior Gradient 2 (AGR2)

Sujet: Anterior gradient 2 (AGR2) is known as a cancer cell marker specifically up-regulated in response to depletion of serum and oxygen. AGR2 has been identified as a tumor marker in primary and secondary cancer lesions, and as a marker for detection of circulating tumor cells (CTCs). Elevated levels of AGR2 are known to increase the metastatic potential of cancer cells, but conditions leading to increased expression of AGR2 are not well understood.

Poids moléculaire: 19979

ID gène: 10551

NCBI Accession: NP_006399

UniProt: O95994