Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Immunogène
This SPPL2a antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 108-138 amino acids from the N-terminal region of human SPPL2a.
anticorps RGD1563001, anticorps SPPL2A, anticorps LOC453430, anticorps LOC100231183, anticorps IMP3, anticorps PSL2, anticorps 2010106G01Rik, anticorps C130089K23Rik, anticorps signal peptide peptidase-like 2A, anticorps signal peptide peptidase like 2A, anticorps Signal peptide peptidase-like 2A, anticorps Sppl2a, anticorps SPPL2A, anticorps sppl2a, anticorps psl2
Sujet
By searching sequence databases for homologs of Dictyostelium discoideum Impas, which shares homology with presenilin, followed by PCR of lymphocyte and hippocampus cDNA libraries, Grigorenko et al. (2002) cloned SPPL2a. This protein, which may act as an intramembrane protease, contains an N-terminal protease-associated (PA) domain, several transmembrane regions, a hydrophilic loop, conservative sequences around the first and second aspartate residues, and an invariant PAL motif near the C terminus.