RCAN1 anticorps (C-Term)

N° du produit ABIN390298

Cet anticorps Lapin Polyclonal détecte spécifiquement RCAN1 dans WB. Il présente une réactivité envers Humain et a été mentionné dans 8+ publications.

Aperçu rapide pour RCAN1 anticorps (C-Term) (ABIN390298)

Antigène: RCAN1 (Regulator of Calcineurin 1 (RCAN1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RCAN1 est non-conjugé

Application: Western Blotting (WB)

Clone: RB4671

Détail du produit anti-RCAN1 anticorps

Épitope: AA 222-252, C-Term

Homologie: B, Ha, M, Rat, Sh

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This RCAN1/DSCR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 222-252 amino acids from the C-terminal region of human DSCR1.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-RCAN1 (ABIN390298)

Wang, Rai, Hur, Smilansky, Chang, Min: "DSCR1 is required for both axonal growth cone extension and steering." dans: The Journal of cell biology, Vol. 213, Issue 4, pp. 451-62, (2017) (PubMed).

Lei, Hu, Chen, Yu, Qi, Du, Gu, Lin, Yang: "RCAN1 deficiency protects against Salmonella intestinal infection by modulating JNK activation." dans: Molecular immunology, Vol. 77, pp. 26-33, (2017) (PubMed).

Hong, Lee, Chung: "Ubiquitin-specific protease 22 (USP22) positively regulates RCAN1 protein levels through RCAN1 de-ubiquitination." dans: Journal of cellular physiology, Vol. 230, Issue 7, pp. 1651-60, (2015) (PubMed).

Junkins, MacNeil, Wu, McCormick, Lin: "Regulator of calcineurin 1 suppresses inflammation during respiratory tract infections." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 190, Issue 10, pp. 5178-86, (2013) (PubMed).

Stefos, Soppa, Dierssen, Becker: "NGF upregulates the plasminogen activation inhibitor-1 in neurons via the calcineurin/NFAT pathway and the Down syndrome-related proteins DYRK1A and RCAN1 attenuate this effect." dans: PLoS ONE, Vol. 8, Issue 6, pp. e67470, (2013) (PubMed).

Wang, Zhu, Chang, Min: "DSCR1 interacts with FMRP and is required for spine morphogenesis and local protein synthesis." dans: The EMBO journal, Vol. 31, Issue 18, pp. 3655-66, (2012) (PubMed).

Hirakawa, Nary, Medh: "Glucocorticoid evoked upregulation of RCAN1-1 in human leukemic CEM cells susceptible to apoptosis." dans: Journal of molecular signaling, Vol. 4, pp. 6, (2009) (PubMed).

Yang, Chen, Edgar, Li, Molkentin, Berman, Lin: "Rcan1 negatively regulates Fc epsilonRI-mediated signaling and mast cell function." dans: The Journal of experimental medicine, Vol. 206, Issue 1, pp. 195-207, (2009) (PubMed).

Détails sur RCAN1

Antigène: RCAN1 (Regulator of Calcineurin 1 (RCAN1))

Autre désignation: DSCR1

Sujet: DSCR1 interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. The gene for this protein is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of DSCR1 may lead to neurofibrillary tangles such as those associated with Alzheimer disease.

Poids moléculaire: 28079

ID gène: 1827

NCBI Accession: NP_004405, NP_981962, NP_981963

UniProt: P53805

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development