PINK1 anticorps (N-Term)

N° du produit ABIN390369

Cité dans 2 publications. Cet anticorps anti-PINK1 Polyclonal Lapin (Clone RB07381) (ABIN390369) détecte spécifiquement PINK1 dans WB et IHC (p). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour PINK1 anticorps (N-Term) (ABIN390369)

Antigène: PINK1 (PTEN Induced Putative Kinase 1 (PINK1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PINK1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB07381

Détail du produit anti-PINK1 anticorps

Épitope: AA 118-147, N-Term

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This PINK1 (PARK6) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 118-147 amino acids from the N-terminal region of human PINK1 (PARK6).

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-PINK1 (ABIN390369)

Wang, Hu, Zou, Xiang, Jiang, Botchway, Huo, Du, Fang: "The post-therapeutic effect of rapamycin in mild traumatic brain-injured rats ensuing in the upregulation of autophagy and mitophagy." dans: Cell biology international, Vol. 41, Issue 9, pp. 1039-1047, (2018) (PubMed).

Zhang, Gu, Chen, Ni, Hung, Wang, Zhang, Feng, Ji: "High expression of PINK1 promotes proliferation and chemoresistance of NSCLC." dans: Oncology reports, Vol. 37, Issue 4, pp. 2137-2146, (2017) (PubMed).

Détails sur PINK1

Antigène: PINK1 (PTEN Induced Putative Kinase 1 (PINK1))

Autre désignation: PINK1 (PARK6)

Sujet: Defects in PINK1 are the cause of autosomal recessive early-onset Parkinson's disease 6 (PARK6). Six novel pathogenic PINK1 mutations suggest that PINK1 may be the second most common causative gene next to parkin in parkinsonism with the recessive mode of inheritance. Strong evidence indicates that, although important in mendelian forms of Parkinson's disease (PD), PINK1 does not influence the cause of sporadic nonmendelian forms of PD.

Poids moléculaire: 62769

ID gène: 65018

NCBI Accession: NP_115785

UniProt: Q9BXM7

Pathways: Autophagy