MTM1 anticorps (C-Term)

N° du produit ABIN390784

Cet anticorps Lapin Polyclonal détecte spécifiquement MTM1 dans WB. Il présente une réactivité envers Humain et Souris et a été mentionné dans 1 publication.

Aperçu rapide pour MTM1 anticorps (C-Term) (ABIN390784)

Antigène: MTM1 (Myotubularin 1 (MTM1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MTM1 est non-conjugé

Application: Western Blotting (WB)

Clone: RB0856

Détail du produit anti-MTM1 anticorps

Épitope: AA 566-594, C-Term

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This MTM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 566-594 amino acids from the C-terminal region of human MTM1.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:2000. WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-MTM1 (ABIN390784)

Jian, Cheng, Jiang, Deng, Hu, Zhang: "A cDNA-based random RNA interference library for functional genetic screens in embryonic stem cells." dans: Stem cells (Dayton, Ohio), Vol. 25, Issue 8, pp. 1904-12, (2007) (PubMed).

Détails sur MTM1

Antigène: MTM1 (Myotubularin 1 (MTM1))

Autre désignation: MTM1

Sujet: MTM1 is a member of a protein family that encodes tyrosine phosphatases. Myotubularin is required for muscle cell differentiation and mutations in MTM1 have been identified as being responsible for X-linked myotubular myopathy. MTM1 is a potent phosphatidylinositol 3-phosphate phosphatase (PI(3)P). Mutations in the MTM1 gene that cause human myotubular myopathy dramatically reduce the ability of the phosphatase to dephosphorylate PI(3)P. The findings provided evidence that myotubularin exerts its effects during myogenesis by regulating the cellular levels of the inositol lipid PI(3)P.

Poids moléculaire: 69932

ID gène: 4534

NCBI Accession: NP_000243

UniProt: Q13496

Pathways: Inositol Metabolic Process, Skeletal Muscle Fiber Development