CERK anticorps (C-Term)

N° du produit ABIN391126

Cet anticorps Lapin Polyclonal détecte spécifiquement CERK dans WB. Il présente une réactivité envers Humain et Souris et a été mentionné dans 3+ publications.

Aperçu rapide pour CERK anticorps (C-Term) (ABIN391126)

Antigène: CERK (Ceramide Kinase (CERK))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CERK est non-conjugé

Application: Western Blotting (WB)

Clone: RB5271

Détail du produit anti-CERK anticorps

Épitope: AA 487-516, C-Term

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This CERK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 487-516 amino acids from the C-terminal region of human CERK.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-CERK (ABIN391126)

Murakami, Ito, Hagiwara, Yoshida, Sobue, Ichihara, Takagi, Kojima, Tanaka, Tamiya-Koizumi, Kyogashima, Suzuki, Banno, Nozawa, Murate: "ATRA inhibits ceramide kinase transcription in a human neuroblastoma cell line, SH-SY5Y cells: the role of COUP-TFI." dans: Journal of neurochemistry, Vol. 112, Issue 2, pp. 511-20, (2010) (PubMed).

Yang, Gagarin, St Laurent, Hammell, Toma, Hu, Iwasa, McCaffrey: "Cardiovascular inflammation and lesion cell apoptosis: a novel connection via the interferon-inducible immunoproteasome." dans: Arteriosclerosis, thrombosis, and vascular biology, Vol. 29, Issue 8, pp. 1213-9, (2009) (PubMed).

Hinkovska-Galcheva, Clark, VanWay, Huang, Hiraoka, Abe, Borofsky, Kunkel, Shanley, Shayman, Lanni, Petty, Boxer: "Ceramide kinase promotes Ca2+ signaling near IgG-opsonized targets and enhances phagolysosomal fusion in COS-1 cells." dans: Journal of lipid research, Vol. 49, Issue 3, pp. 531-42, (2008) (PubMed).

Détails sur CERK

Antigène: CERK (Ceramide Kinase (CERK))

Autre désignation: CERK

Sujet: Ceramide kinases convert the sphingolipid metabolite ceramide into ceramide-1-phosphate, both key mediators of cellular apoptosis and survival. Ceramide metabolism plays an essential role in the viability of neuronal cells, the membranes of which are particularly rich in sphingolipids. CERK catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. This enzyme acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8 dihydroceramide), and to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines. High level expression is noted in heart, brain, skeletal muscle, kidney and liver, moderate expression in peripheral blood leukocytes and thymus, and low expression in spleen, small intestine, placenta and lung.

ID gène: 64781

NCBI Accession: NP_073603

UniProt: Q8TCT0