BRSK2 anticorps (C-Term)

N° du produit ABIN391285

Détail du produit anti-BRSK2 anticorps

Antigène: BRSK2 (BR serine/threonine Kinase 2 (BRSK2))

Épitope: AA 706-736, C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BRSK2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This STK29 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 706-736 amino acids from the C-terminal region of human STK29.

Clone: RB5548

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Détails sur BRSK2

Antigène: BRSK2 (BR serine/threonine Kinase 2 (BRSK2))

Autre désignation: STK29 (BRSK2 Produits)

Synonymes: anticorps C11orf7, anticorps PEN11B, anticorps SAD1, anticorps SADA, anticorps STK29, anticorps BRSK2, anticorps 4833424K13Rik, anticorps SAD-A, anticorps BR serine/threonine kinase 2, anticorps BRSK2, anticorps Brsk2

Sujet: BRSK2 expressed in insect cells specifically phosphorylates WEE1A, CDC25C, and CDC25B in an in vitro assay, but a kinase-dead mutant does not. Overexpression of BRSK2 in HeLa cells results in increased phosphorylation of CDC25C. DNA damage induced by ultraviolet (UV) irradiation or methyl methane sulfonate, but not by ionizing radiation, enhances endogenous BRSK2 kinase activity in a caffeine-sensitive manner and causes translocation of BRSK2 from the cytoplasm to the nucleus. Overexpression of BRSK2 induces G2/M arrest in HeLa cells. Small interfering RNA against BRSK2 partly abrogates UV-induced G2/M arrest. BRSK2 may act as a checkpoint kinase upon DNA damage induced by UV irradiation or methyl methane sulfonate.

Poids moléculaire: 81633

ID gène: 9024

NCBI Accession: NP_001243556, NP_001243558, NP_001243559, NP_003948

UniProt: Q8IWQ3