DYRK1B anticorps (C-Term)

N° du produit ABIN391774

Cet anticorps Lapin Polyclonal détecte spécifiquement DYRK1B dans WB et IHC (p). Il présente une réactivité envers Humain et Souris et a été mentionné dans 4+ publications.

Aperçu rapide pour DYRK1B anticorps (C-Term) (ABIN391774)

Antigène: DYRK1B (Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1B (DYRK1B))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DYRK1B est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB3017

Détail du produit anti-DYRK1B anticorps

Épitope: AA 561-589, C-Term

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This DYRK1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 561-589 amino acids from the C-terminal region of human DYRK1B.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-DYRK1B (ABIN391774)

Gao, Zhao, Lv, Chen, Wei, Tian, Yang, Kong, Pang, Liu, Shi: "Mirk/Dyrk1B mediates G0/G1 to S phase cell cycle progression and cell survival involving MAPK/ERK signaling in human cancer cells." dans: Cancer cell international, Vol. 13, Issue 1, pp. 2, (2013) (PubMed).

Gao, Yang, Yin, Hu, Liao, Miao, Pan, Li: "The involvement of FoxO in cell survival and chemosensitivity mediated by Mirk/Dyrk1B in ovarian cancer." dans: International journal of oncology, Vol. 40, Issue 4, pp. 1203-9, (2012) (PubMed).

Lee, Ha, Kim, Kim, Chang, Song, Kim: "Negative feedback Inhibition of NFATc1 by DYRK1A regulates bone homeostasis." dans: The Journal of biological chemistry, Vol. 284, Issue 48, pp. 33343-51, (2009) (PubMed).

Takahashi-Yanaga, Mori, Matsuzaki, Watanabe, Hirata, Miwa, Morimoto, Sasaguri: "Involvement of GSK-3beta and DYRK1B in differentiation-inducing factor-3-induced phosphorylation of cyclin D1 in HeLa cells." dans: The Journal of biological chemistry, Vol. 281, Issue 50, pp. 38489-97, (2006) (PubMed).

Détails sur DYRK1B

Antigène: DYRK1B (Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1B (DYRK1B))

Autre désignation: DYRK1B

Sujet: DYRK1B is a member of the DYRK family of protein kinases. DYRK1B contains a bipartite nuclear localization signal and is found mainly in muscle and testis. The protein is proposed to be involved in the regulation of nuclear functions. Three isoforms of DYRK1B have been identified differing in the presence of two alternatively spliced exons within the catalytic domain.

Poids moléculaire: 69198

ID gène: 9149

NCBI Accession: NP_004705, NP_006474, NP_006475

UniProt: Q9Y463