Integrin-Linked Kinase (ILK) (AA 11-41), (N-Term) anticorps

Détails pour le produit réf. ABIN391993, Fournisseur: Connectez-vous pour afficher
Antigène
  • CG10504
  • CT29478
  • DmILK
  • Dmel\\CG10504
  • ILK
  • ilk
  • l(3)78Ca
  • p59
  • AA511515
  • ESTM24
  • zgc:65842
  • ILK-1
  • ILK-2
  • P59
  • p59ILK
  • Integrin linked kinase
  • integrin linked kinase
  • integrin linked kinase S homeolog
  • integrin-linked protein kinase
  • integrin-linked kinase
  • Ilk
  • ILK
  • ilk.S
  • CpipJ_CPIJ016644
  • Bm1_20815
  • Tsp_07213
  • Tsp_07224
  • Tsp_15354
  • ilk
Épitope
AA 11-41, N-Term
37
29
27
15
15
15
13
10
9
8
7
7
7
4
4
3
3
3
3
3
2
2
2
1
1
1
1
1
1
1
1
Reactivité
Humain
255
112
96
4
3
2
2
1
1
1
1
1
1
1
Hôte
Lapin
231
13
13
Clonalité (Clone)
Polyclonal ()
Conjugué
Inconjugué
17
16
16
11
11
11
3
3
3
3
3
3
3
3
3
3
3
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
166
146
111
39
29
23
13
7
6
6
5
5
3
2
1
Options
Fournisseur
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N° du produit (Fournisseur)
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Immunogène This ILK1/ILK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 11-41 AA from the N-terminal region of human ILK1/ILK2.
Clone RB1668
Isotype Ig Fraction
Homologie Cow (Bovine),Rat (Rattus)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Antigène
Autre désignation ILK1/ILK2 (ILK Antibody Extrait)
Sujet Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase (ILK), interacts with the cytoplasmic domain of beta-1 integrin. ILK encodes a predicted 451-amino acid protein, with an apparent molecular weight of 59 kD. The ILK protein is a serine/threonine protein kinase with 4 ankyrin-like repeats. ILK regulates integrin-mediated signal transduction.
Synonyms: Integrin-linked kinase 1
Poids moléculaire 51419 DA
ID gène 16202
UniProt O55222
Pathways Regulation of Muscle Cell Differentiation, Regulation of Cell Size, Maintenance of Protein Location, Skeletal Muscle Fiber Development, Smooth Muscle Cell Migration
Indications d'application WB = 1:1000, IHC (p) = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 1.43 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Agent conservateur Sodium azide
Précaution d'utilisation This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock 4 °C/-20 °C
Stockage commentaire Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Date de péremption 6 months
Images (Fournisseur)
Western Blotting (WB) image for anti-Integrin-Linked Kinase (ILK) (AA 11-41), (N-Term) antibody (ABIN391993) Western blot analysis of anti-ILK1 Pab (ABIN391993) in HL60 cell lysate. ILK1 (Arrow)...
Immunohistochemistry (IHC) image for anti-Integrin-Linked Kinase (ILK) (AA 11-41), (N-Term) antibody (ABIN391993) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary ant...
Immunohistochemistry (IHC) image for anti-Integrin-Linked Kinase (ILK) (AA 11-41), (N-Term) antibody (ABIN391993) Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with ILK1/I...
Produit citée dans: Schramm, Opitz, Thies, Seifert, Moch, Weder, Soltermann: "Prognostic significance of epithelial-mesenchymal transition in malignant pleural mesothelioma." dans: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Vol. 37, Issue 3, pp. 566-72, 2010 (PubMed). Méthode utilisée: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Samara, Laguinge, Jessup: "Carcinoembryonic antigen inhibits anoikis in colorectal carcinoma cells by interfering with TRAIL-R2 (DR5) signaling." dans: Cancer research, Vol. 67, Issue 10, pp. 4774-82, 2007 (PubMed). Méthode utilisée: Western Blotting (WB)

Background publications Troussard, Mawji, Ong, Mui, St -Arnaud, Dedhar: "Conditional knock-out of integrin-linked kinase demonstrates an essential role in protein kinase B/Akt activation." dans: The Journal of biological chemistry, Vol. 278, Issue 25, pp. 22374-8, 2003 (PubMed).

Marotta, Parhar, Owen, Dedhar, Salh: "Characterisation of integrin-linked kinase signalling in sporadic human colon cancer." dans: British journal of cancer, Vol. 88, Issue 11, pp. 1755-62, 2003 (PubMed).

Cordes, van Beuningen: "Cell adhesion to the extracellular matrix protein fibronectin modulates radiation-dependent G2 phase arrest involving integrin-linked kinase (ILK) and glycogen synthase kinase-3beta (GSK-3beta) in vitro." dans: British journal of cancer, Vol. 88, Issue 9, pp. 1470-9, 2003 (PubMed).

Fukuda, Guo, Shi, Wu: "CH-ILKBP regulates cell survival by facilitating the membrane translocation of protein kinase B/Akt." dans: The Journal of cell biology, Vol. 160, Issue 7, pp. 1001-8, 2003 (PubMed).

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