CXCR2
Reactivité: Humain, Souris, Rat
WB, IHC, IP
Hôte: Lapin
Polyclonal
unconjugated
Indications d'application
Flow Cytometry. Immunohistochemistry on Paraffin Sections: 2.5-5.0 μg/mL. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Buffer
PBS without preservatives.
Agent conservateur
Without preservative
Stock
4 °C/-20 °C
Stockage commentaire
Store the antibody undiluted at 2-8 °C for one month or (Add 40-50% Glycerol) at -20 °C forlonger. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
CXCR2 is a receptor for Interleukin 8, which is a powerful neutrophil chemotactic factor. It is a member of the GPCR family (subfamily, chemokine). Binding of IL8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL8 with a high affinity and to GRO/MGSA and NAP2 also with a high affinity. It has been reported to be expressed in a wide variety of tissues. ESTs have been isolated from human placenta and thymus libraries.Synonyms: CDw128b, CXCR-2, CXCR2, GRO/MGSA receptor, IL-8 receptor type 2, IL8 receptor beta