TP53BP2 anticorps

N° du produit ABIN401045

L’anticorps anti-TP53BP2 Polyclonal Lapin est utilisé pour la détection de TP53BP2 dans des échantillons de Humain, Chien et Macaque. Il a été validé pour WB et EIA.

Aperçu rapide pour TP53BP2 anticorps (ABIN401045)

Antigène: TP53BP2 (Tumor Protein P53 Binding Protein 2 (TP53BP2))

Reactivité: Humain, Chien, Macaque

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TP53BP2 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Détail du produit anti-TP53BP2 anticorps

Specificité: This antibody is directed against ASPP2.

Réactivité croisée (Details): Species reactivity (expected):Canine (100 %), Macaque (100 %), Mouse (80 %), Rat (80 %).
Species reactivity (tested):Human.

Purification: Affinity Chromatography on Protein A

Immunogène: Synthetic peptide corresponding to an internal sequence of Human ASPP2 . Genename: ASPP2

Isotype: IgG

Information d'application

Indications d'application: ELISA: 1/2,500-1/10,000. Western Blot: 1/500-1/3,000. Expect a band approximately 125 kDa in size correspondingto ASPP2 in the appropriate cell lysate or extract.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 2.4 mg/mL (by UV absorbance at 280 nm)

Buffer: 0.02 M Potassium Phosphate, 0.12 M Sodium Chloride, pH 7.2 containing 0.01 % (w/v) Sodium Azide as preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer. Dilute only prior to immediate use.

Détails sur TP53BP2

Antigène: TP53BP2 (Tumor Protein P53 Binding Protein 2 (TP53BP2))

Autre désignation: TP53BP2

Sujet: ASPP (ankyrinrepeat-, SH3-domain- proline-rich-region protein) proteins (ASPP1, ASPP2 and iASPP) represent a new family of p53 binding proteins. ASPP1 and ASPP2 bind and enhance p53-mediated apoptosis. In contrast, iASPP functionally inactivates p53. ASPPs may also regulate p63-and p73-mediated apoptosis. Both ASPP1 and 2 directly interact with p53 and specifically enhance the apoptotic function of p53 by stimulating its DNA binding and transactivation function on promoters of pro-apoptotic genes, such as Bax and PIG-3. Not all cell cycle arrest genes are affected, such as p21. Interestingly, expression of ASPP is frequently down-regulated in human breast carcinomas expressing wild-type p53 but not mutant p53. Therefore, ASPP might regulate the tumor suppression function of p53 in vivo.Synonyms: 53BP2, ASPP2, Apoptosis-stimulating of p53 protein 2, BBP, Bcl2-binding protein, NY-REN-51, Tumor suppressor p53-binding protein 2, p53-binding protein 2, p53BP2

ID gène: 7159

NCBI Accession: NP_001026855

UniProt: Q13625