SLIT2 anticorps (AA 484-500)

N° du produit ABIN401286

Détail du produit anti-SLIT2 anticorps

Antigène: SLIT2 (Slit Homolog 2 (Drosophila) (SLIT2))

Épitope: AA 484-500

Reactivité: Humain, Rat, Souris, Poulet, Boeuf (Vache), Tetraodon nigroviridis, Xenopus laevis

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SLIT2 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificité: This antibody is directed against SLIT-2 protein.

Réactivité croisée (Details): Species reactivity (expected):Chicken, Mouse, Rat, Bovine, Xenopus laevis.
Species reactivity (tested):Human.

Purification: Affinity Chromatography

Immunogène: Synthetic peptide corresponding aa 484-500 of Human SLIT-2 protein.

Isotype: IgG

Information d'application

Indications d'application: ELISA: 1/1,500 - 1/6,000. Western Blot: 1/500 - 1/2,000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL (by UV absorbance at 280 nm)

Buffer: 0.02 M Potassium Phosphate, 0.12 M Sodium Chloride, pH 7.2 containing 0.01 % (w/v) Sodium Azide as preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted 2-8 °C fo one month or (in aliquots) at-20 °C for longer.

Détails sur SLIT2

Antigène: SLIT2 (Slit Homolog 2 (Drosophila) (SLIT2))

Autre désignation: SLIT2 (SLIT2 Produits)

Synonymes: anticorps SLIL3, anticorps Slit-2, anticorps Drad-1, anticorps E030015M03Rik, anticorps E130320P19Rik, anticorps Slil3, anticorps mKIAA4141, anticorps Slit, anticorps slil3, anticorps slit-2, anticorps slit2-a, anticorps SLIT2, anticorps slit guidance ligand 2, anticorps slit homolog 2 (Drosophila), anticorps slit guidance ligand 2 S homeolog, anticorps SLIT2, anticorps Slit2, anticorps slit2, anticorps slit2.S

Sujet: SLIT-2 is thought to act as a molecular guidance cue in cellular migration, and its function appears to be mediated by interaction with roundabout homologue receptors. SLIT-1 and SLIT-2 seem to be essential for midline guidance in the forebrain by acting as repulsive signals preventing inappropriate midline crossing by axons projecting from the olfactory bulb. In spinal chord development SLIT-2 may play role in guiding commissural axons once they reach the floor plate by modulating the response to netrin. In vitro, SLIT-2 silences the attractive effect of NTN1 but not its growthstimulatory effect and silencing requires the formation of a ROBO1-DCC complex. In vitro, only commissural axons that crossed the midline responded to SLIT-2. In the developing visual system this protein functions as a repellent for retinal ganglion axons by providing a repulsion that directs these axons along their appropriate paths prior to, and after passage through, the optic chiasm. SLIT-2 is a secreted protein predominantly expressed in fetal lung and kidney, and adult spinal cord. Weak expression is observed in adult adrenal gland, thyroid, trachea and other tissues examined. Multiple isoforms have been reported for this product.Synonyms: SLIL3, SLIT-2, Slit homolog 2 protein

ID gène: 9353

NCBI Accession: NP_004778

UniProt: O94813

Pathways: Regulation of Actin Filament Polymerization, Regulation of Cell Size, Smooth Muscle Cell Migration