UBASH3B anticorps (C-Term)

N° du produit ABIN401302

Cet anticorps Lapin Polyclonal détecte spécifiquement UBASH3B dans WB et EIA. Il présente une réactivité avec des échantillons de Humain, Souris, Rat et Chien.

Aperçu rapide pour UBASH3B anticorps (C-Term) (ABIN401302)

Antigène: UBASH3B (STS1) (Cbl-Interacting Protein Sts-1 (STS1))

Reactivité: Humain, Souris, Rat, Chien

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp UBASH3B est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Détail du produit anti-UBASH3B anticorps

Épitope: C-Term

Specificité: This antibody is directed against Sts-1 protein.

Réactivité croisée (Details): Species reactivity (expected):Rat, Human.
Species reactivity (tested):Mouse.

Purification: Affinity chromatography

Immunogène: Synthetic peptide corresponding to the C-terminus of mouse Sts-1

Isotype: IgG

Information d'application

Indications d'application: ELISA: 1/2,000 - 1/10,000. Western Blot: 1/500 - 1/3,000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0.63 mg/mL (by UV absorbance at 280 nm)

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.01 % (w/v) Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Détails sur UBASH3B

Antigène: UBASH3B (STS1) (Cbl-Interacting Protein Sts-1 (STS1))

Autre désignation: UBASH3B / STS1

Sujet: Sts-1 is a protein that inhibits endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor. Sts-1 and Sts-2 (formerly p70 and Clip4, respectively) have been found to interact with Cbl, an ubiquitin ligase that plays a critical role in attenuation of receptor tyrosine kinase signaling by inducing ubiquitination and promoting their sorting for endosomal degradation. Sts-1 and Sts-2 contain SH3 domains that interact with Cbl, Ub-associated domains, which bind directly to mono-Ub or to the EGFR/Ub chimera, as well as phosphoglycerate mutase domains that mediate oligomerization of Sts-1/2. Sts-1 and Sts-2 also have been found to negatively regulate signaling pathways that control T cell receptors, which in turn affect the extent and duration of the T cell response to foreign pathogens.Synonyms: Cbl-interacting protein p70, KIAA1959, STS-1, Suppressor of T-cell receptor signaling 1, Ubiquitin-associated and SH3 domain-containing protein B

ID gène: 84959

NCBI Accession: NP_116262

UniProt: Q8TF42