GPX4 anticorps (C-Term)

N° du produit ABIN401375

L’anticorps Lapin Polyclonal anti-GPX4 a été validé pour WB et EIA. Il convient pour détecter GPX4 dans des échantillons de Humain, Souris, Rat et Cobaye.

Aperçu rapide pour GPX4 anticorps (C-Term) (ABIN401375)

Antigène: GPX4 (Glutathione Peroxidase 4 (GPX4))

Reactivité: Humain, Souris, Rat, Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GPX4 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Détail du produit anti-GPX4 anticorps

Épitope: C-Term

Specificité: This antibody is directed against GPx4 protein.

Réactivité croisée (Details): Species reactivity (expected):Rat, Guinea Pig, Human.
Species reactivity (tested):Mouse.

Purification: Affinity chromatography

Immunogène: Synthetic peptide corresponding to amino acids near the carboxyl terminus of mouse GPx4 protein

Isotype: IgG

Information d'application

Indications d'application: ELISA: 1/7,000 - 1/30,000. Western Blot: 1/500 - 1/3,000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.15 mg/mL (by UV absorbance at 280 nm)

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.01 % (w/v) Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Détails sur GPX4

Antigène: GPX4 (Glutathione Peroxidase 4 (GPX4))

Autre désignation: Glutathione Peroxidase 4 / GPX4

Sujet: Glutathione Peroxidase 4 (GPx4, also known as PHGPx) functions as an antioxidant and also plays a role in redox regulation, sexual maturation, inflammation, apoptosis, and differentiation. GPx4 was found to have an important role in preventing lipid peroxidation, and has been discussed primarily as the glutathione peroxidase protecting biomembranes against oxidative stress. GPx4 can react with free hydrogen peroxide as well as with a wide range of lipid hydroperoxides, including those derived from cholesterol and cholesteryl esters. GPx4 is the only GPx to use phospholipid hydroperoxides as substrates. It can also reduce thymine hydroperoxide. In contrast to GPx1 and GPx3, GPx4 can use a wide range of reducing substrates in addition to glutathione. GPx4 is expressed in high levels in testes, suggesting a role in male fertility. It has also been identified as an enzymatically inactive structural protein of the mitochondrial capsule of sperm.Synonyms: GPx-4, Phospholipid hydroperoxide glutathione peroxidase mitochondrial

ID gène: 2879

NCBI Accession: NP_001034936

UniProt: P36969