TDGF1 anticorps (Internal Region)

N° du produit ABIN401391

Cet anticorps anti-TDGF1 est un anticorps Lapin Polyclonal détectant TDGF1 dans WB et EIA. Adapté pour Humain et Souris.

Aperçu rapide pour TDGF1 anticorps (Internal Region) (ABIN401391)

Antigène: TDGF1 (Teratocarcinoma-Derived Growth Factor 1 (TDGF1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TDGF1 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Détail du produit anti-TDGF1 anticorps

Épitope: Internal Region

Specificité: This antibody is specific for Cripto-1 protein. Expect cross-reactivity with Cripto-3 (TDGF2) based on very high levels of sequence conservation.

Réactivité croisée (Details): Species reactivity (expected):Mouse.
Species reactivity (tested):Human.

Purification: Affinity chromatography

Immunogène: Synthetic peptide corresponding to an internal sequence of human Cripto-1 protein

Isotype: IgG

Information d'application

Indications d'application: ELISA: 1/50,000 - 1/150,000. Western Blot: 1/500 - 1/2,000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0.80 mg/mL (by UV absorbance at 280 nm)

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.01 % (w/v) Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Détails sur TDGF1

Antigène: TDGF1 (Teratocarcinoma-Derived Growth Factor 1 (TDGF1))

Autre désignation: TDGF1 / CRIPTO

Sujet: Human Cripto-1 (CR-1), also known as Teratocarcinoma-derived growth factor 1 (TDGF1), is a member of the epidermal growth factor (EGF)-GFC family and has been implicated in both embryogenesis and carcinogenesis. During early vertebrate development, CR-1 functions as a co-receptor for Nodal, a transforming growth factor beta (TGFbeta) family member, and is essential for mesoderm and endoderm formation and anterior-posterior and left-right axis establishment. In adult tissues, CR-1 is expressed at a low level in all stages of mammary gland development, and expression increases during pregnancy and lactation. Over-expression of CR-1 in mouse mammary epithelial cells leads to their transformation in vitro, and when injected in mammary glands, CR-1 produces ductal hyperplasias.Synonyms: CRGF, Cripto-1 growth factor, Epidermal growth factor-like cripto protein CR1, Teratocarcinoma-derived growth factor 1

ID gène: 6997

NCBI Accession: NP_001167607

UniProt: P13385

Pathways: EGFR Signaling Pathway