EIF3E anticorps (C-Term)

N° du produit ABIN401422

Détail du produit anti-EIF3E anticorps

Antigène: EIF3E (Eukaryotic Translation Initiation Factor 3 Subunit E (EIF3E))

Épitope: C-Term

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Singe

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EIF3E est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificité: This antibody is specific for Mouse eIF3S6/Int6 protein.

Réactivité croisée (Details): Species reactivity (expected):Human, Rat, Canine, Bovine, Monkey.
Species reactivity (tested):Mouse.

Purification: Immunoaffinity Chromatography.

Immunogène: Synthetic peptide corresponding to a region near the C-terminus of mouse EIF3S6/Int6 . Genename: EIF3E

Isotype: IgG

Information d'application

Indications d'application: Suitable for use in ELISA (1/80,000) and Western Blot (1/1,000). Expect a band approx. 48 kDa in size corresponding to eIF3S6/Int6 by Western blotting in theappropriate cell lysate or extract. This antibody is capable of detecting bothover-expressed and endogenous eIF3S6/Int6.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0.8 mg/mL (by UV absorbance at 280 nm)

Buffer: 0.02 M Potassium Phosphate, 0.12 M Sodium Chloride, pH 7.2 containing 0.01 % (w/v) Sodium Azide as preservative.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Détails sur EIF3E

Antigène: EIF3E (Eukaryotic Translation Initiation Factor 3 Subunit E (EIF3E))

Autre désignation: EIF3E / EIF3S6 (EIF3E Produits)

Synonymes: anticorps EIF3-P48, anticorps EIF3S6, anticorps INT6, anticorps eIF3-p46, anticorps 48kDa, anticorps Eif3s6, anticorps Int6, anticorps eIF3-p48, anticorps eif3-p48, anticorps eif3s6, anticorps eif3s6-A, anticorps eIF3e, anticorps eIF3-S6, anticorps eif3s6-B, anticorps EIF3SE, anticorps eif3s6b, anticorps im:7147439, anticorps QtsA-18056, anticorps eukaryotic translation initiation factor 3 subunit E, anticorps eukaryotic translation initiation factor 3, subunit E, anticorps eukaryotic translation initiation factor 3 subunit E L homeolog, anticorps eukaryotic translation initiation factor 3 subunit 6, anticorps eukaryotic translation initiation factor 3 subunit E S homeolog, anticorps eukaryotic translation initiation factor 3, subunit E, a, anticorps Eukaryotic translation initiation factor 3 subunit E, anticorps eukaryotic translation initiation factor 3, subunit E, b, anticorps EIF3E, anticorps Eif3e, anticorps eif3e, anticorps eif3e.L, anticorps LOC692936, anticorps eif3e.S, anticorps eif3ea, anticorps eif-3.E, anticorps eif3eb, anticorps LOC108348260, anticorps int6

Sujet: Int6 is a candidate tumor suppressor in multiple neoplasms, and in particular, breast and lung cancers. The Int6 locus was initially identified as a common insertion site (CIS) in a genetic screen for transforming sequences in a breast cancer mouse model system. Insertion of mouse mammary tumor virus (MMTV) into this locus results in the production of an amino-terminal truncated gene product. Expression of the truncated Int6 product corresponds to cellular transformation in both in vivo and in vitro systems. This gene product plays a role in regulating translation initiation and is a component of the eIF3 translation initiation complex. There is evidence that suggests that Int6 may impart a negative role in the general translational machinery while promoting an increase in the expression of a subset of stress-responsive genes. Taken together, it is of great interest to further study the mechanism by which Int6 is involved in regulating cell growth.Synonyms: Eukaryotic translation initiation factor 3 subunit 6, Eukaryotic translation initiation factor 3 subunit E, INT6, Viral integration site protein INT-6 homolog, eIF-3 p48

ID gène: 16341

NCBI Accession: NP_032414

UniProt: P60229

Pathways: Ribonucleoprotein Complex Subunit Organization, Hepatitis C