TNKS2 anticorps (AA 800-900)

N° du produit ABIN401534

Détail du produit anti-TNKS2 anticorps

Antigène: TNKS2 (Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 2 (TNKS2))

Épitope: AA 800-900

Reactivité: Humain, Souris, Chien

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp TNKS2 est non-conjugé

Application: Western Blotting (WB)

Specificité: This antibody detects Tankyrase-2 (TANK2). No cross-reactivity expected with TANK1.

Réactivité croisée (Details): Species reactivity (expected):Mouse and Canine (Dog).
Species reactivity (tested):Human.

Purification: Ammonium Sulphate Precipitation followed by Affinity Chromatography using the immunizing peptide.

Immunogène: Fusion protein containing 73 aa from aa 800-900 region of the protein sequence according to NP_079511.1. Genename: TNKS2

Information d'application

Indications d'application: Western blot: 0.5-1.5 μg/mL. In transfected HEK293 transiently expressing TANK2 a band of approx.127 kDa is observed. This band is not observed in the non-transfected HEK293. The calculated molecular size is127 kDa according to NP_079511.1. Full caption (see picture below): HEK293 overexpressing TANK2 (lane 4) and TANK1 (lane 2)and probed with ABIN401534 (mock transfection in first lane). Lane three is empty. Lowerpanel shows the same lysates probed for alpha-Actin to show protein levels. Primaryincubation (0.5 μg/mL) was overnight at 4 °C. Detected by chemiluminescence.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Détails sur TNKS2

Antigène: TNKS2 (Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 2 (TNKS2))

Autre désignation: Tankyrase-2 (TANK2) (TNKS2 Produits)

Synonymes: anticorps ARTD6, anticorps PARP-5b, anticorps PARP-5c, anticorps PARP5B, anticorps PARP5C, anticorps TANK2, anticorps TNKL, anticorps pART6, anticorps 5430432P15Rik, anticorps AA517131, anticorps AI662480, anticorps TNKS-2, anticorps Tank2, anticorps tankyrase-2, anticorps TNKS2, anticorps tankyrase-1, anticorps tnks, anticorps tnks.L, anticorps tnks2, anticorps tankyrase 2, anticorps tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2, anticorps tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase S homeolog, anticorps TNKS2, anticorps Tnks2, anticorps tnks2, anticorps tnks.S

Sujet: Tankyrase 2 may regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. It has PARP activity and can modify TRF1, and thereby contribute to the regulation of telomere length. Tankyrase 2 is highly expressed in placenta, skeletal muscle, liver, brain, kidney, heart, thymus, spinal cord, lung, peripheral blood leukocytes, pancreas, lymph nodes, spleen, prostate, testis, ovary, small intestine, colon, mammary gland, breast and breast carcinoma, and in common-type meningioma. Also highly expressed in fetal liver, heart and brain. Tankyrase 2 shares approximately 83 % sequence identity with Tankyrase 1.Synonyms: PARP5B, TNKL, TNKS-2, TNKS2, TRF1-interacting ankyrin-related ADP-ribose polymerase 2, Tankyrase II, Tankyrase-like protein, Tankyrase-related protein

ID gène: 80351

NCBI Accession: NP_079511

UniProt: Q9H2K2