KDELR1 anticorps

N° du produit ABIN452265

Cet anticorps anti-KDELR1 Monoclonal Souris (Clone KR-10) (ABIN452265) détecte spécifiquement KDELR1 dans WB, IF, IP et IHC (fro). L’anticorps est réactif avec des échantillons de Différentes espèces.

Aperçu rapide pour KDELR1 anticorps (ABIN452265)

Antigène: KDELR1 (KDEL (Lys-Asp-Glu-Leu) Endoplasmic Reticulum Protein Retention Receptor 1 (KDELR1))

Reactivité: Différentes espèces

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp KDELR1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: KR-10

Détail du produit anti-KDELR1 anticorps

Réactivité croisée (Details): Species reactivity (tested):Human, Monkey, Mouse, Rat, Hamster, Rabbit, Pig, Bovine, Sheep, Canine, Chicken, Drosphilia, Xenopus

Attributs du produit: Synonyms: KDEL endoplasmic reticulum protein retention receptor 1, ERD2.1, ER marker, ER lumenprotein retaining receptor 1, Putative MAPK-activating protein PM23

Purification: Protein G chromatography

Immunogène: A 21 residue synthetic peptide based on the bovine KDEL receptor and the peptide coupledto KLH

Isotype: IgG1

Information d'application

Indications d'application: Immunoprecipitation (1). Immunocytochemistry (3). Immunohistochemisztry on frozen sections. Western blot (2).

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS pH 7.2, in 50 % glycerol with 0.09 % azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoidrepeated freezing and thawing.
Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur KDELR1

Antigène: KDELR1 (KDEL (Lys-Asp-Glu-Leu) Endoplasmic Reticulum Protein Retention Receptor 1 (KDELR1))

Autre désignation: KDEL Receptor 1 / KDELR1

Sujet: The endoplasmic reticulum is part of a protein sorting pathway, or in essence, the transportation system of the eukaryotic cell. The majority of endoplasmic reticulum resident proteins are retained in the endoplasmic reticulum through a retention motif. This motif is composed of four amino acids at the C-terminal end of the protein sequence. The most common retention sequence is KDEL (lys-asp-glu-leu). However, variation on KDEL does occur and other sequences can also give rise to endoplasmic reticulum retention (6). There are three KDEL receptors in mammalian cells, all have a very high degree of sequence identity, and all are located within the cis-Golgi and its intermediate compartments (4). In terms of function, KDEL receptors interact with GAP (GTPase-activating protein) of ARF1, which is involved in COPI dependent vesicle transport, and the KDEL receptor may also be responsible for the recruitment of this ARF1 to membranes which can then aid in the regulation of vesicle budding (3). It is also important to note that the KDEL receptor exhibits extensive sequence identity o yeast protein Erd2p, which is a receptor for the yeast ER retention signal (4, 5).Synonyms: ER lumen protein retaining receptor 1, ER marker, ERD2.1, KDEL endoplasmic reticulum protein retention receptor 1, Putative MAPK-activating protein PM23

ID gène: 618184

UniProt: P33946

Pathways: Maintenance of Protein Location