FKBP4 anticorps

N° du produit ABIN452368

Cet anticorps Souris Monoclonal détecte spécifiquement FKBP4 dans WB, IP et IHC (p). Il présente une réactivité avec des échantillons de Humain, Souris, Rat, Hamster et Chien.

Aperçu rapide pour FKBP4 anticorps (ABIN452368)

Antigène: FKBP4 (FK506 Binding Protein 4, 59kDa (FKBP4))

Reactivité: Humain, Souris, Rat, Hamster, Chien

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp FKBP4 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: Hi52C

Détail du produit anti-FKBP4 anticorps

Specificité: This antibody detects an ~52 kDa protein representing FKBP52 in HeLa cell lysate. Also detects FKBP52 in whole tissue extracts from Rat kidney and Rat and Mouse testes. Heavy chain migrates close to FKBP52 on SDS-PAGE.

Réactivité croisée (Details): Species reactivity (tested):Canine, Hamster, Human, Mouse, Rat

Attributs du produit: Synonyms: FK506-binding protein 4, FKBP52 protein, FKBP59, p59 protein, Peptidyl-prolyl cis-transisomerase, PPIase, HSP-binding immunophilin, HBI, 52 kDa FK506-binding protein,Rotamase

Purification: Protein G Chromatography

Immunogène: Synthetic peptide corresponding to the residues of human FKBP52

Isotype: IgG1

Information d'application

Indications d'application: Western blot (1): 1: 2000. Immunoprecipitation (1): 5 μg with 10-20 μL Protein A beads. Imunohistochemistry on paraffin embedded sections (1): 1: 250.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS in 50 % Glycerol, 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoidrepeated freezing and thawing.
Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur FKBP4

Antigène: FKBP4 (FK506 Binding Protein 4, 59kDa (FKBP4))

Autre désignation: FKBP4

Sujet: Hsp90 is crucial to cellular signaling by its regulation of the folding, activity, and stability of a wide range of client proteins. These client protein complexes may also contain one or more cochaperones (1). One class of Hsp90-binding cochaperone is composed of proteins with a characteristic tetratricopeptide repeat (TPR) domain that forms an Hsp90 binding site. Among the TPR cochaperones of Hsp90 are Hop/Sti1, protein phosphatase PP5, and members of both the FK506- and cyclosporin Abinding families of immunophilins (2). FK506-binding protein 51 (FKBP51) and FKBP52 are large molecular weight immunophilins that are part of the mature glucocorticoid receptor (GR) heterocomplex (3). The N terminal domain of each protein binds FK506 and has peptidyl-prolyl isomerase (PPIase) activity that converts prolyl peptide bonds within target proteins from cis- to trans- proline. The C-terminal domains contain the TPR repeats involved in protein-protein interactions with the Hsp90 (4). Although FKBP52 and FKBP51 share ~75 % sequence similarity, they affect hormone binding by glucocorticoid receptor in opposing manners and have different Hsp90-binding characteristics (3, 5). Also, whereas FKBP51 typically has a role with the progesterone receptor, FKBP52 has been found to be linked to the progesterone, androgen and glucocorticoid receptors (5).Synonyms: 52 kDa FK506-binding protein, FK506-binding protein 4, FKBP52 protein, FKBP59, HBI, HSP-binding immunophilin, PPIase, Peptidyl-prolyl cis-trans isomerase, Rotamase, p59 protein

ID gène: 2288

UniProt: Q02790

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway