HCV Core Protein anticorps

N° du produit ABIN452510

L’anticorps Souris Monoclonal anti-HCV Core Protein a été validé pour EIA. Il convient pour détecter HCV Core Protein dans des échantillons de Humain.

Aperçu rapide pour HCV Core Protein anticorps (ABIN452510)

Antigène: HCV Core Protein (HCV C) (Hepatitis C Virus Core Protein (HCV C))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp HCV Core Protein est non-conjugé

Application: Enzyme Immunoassay (EIA)

Clone: A1-3D1

Détail du produit anti-HCV Core Protein anticorps

Réactivité croisée (Details): Species reactivity (tested):Human.

Attributs du produit: Synonyms: Hepatitis C Virus

Purification: Affinity chromatography on Protein G.

Immunogène: Synthetic peptides derived from HCV Capsid Protein

Isotype: IgG1

Information d'application

Indications d'application: ELISA: HCV Core Protein antibody (clone A1/3D1) was tested using indirect ELISA method. The testing plates were coated with HCV non-structural protein (NS), Capsid Protein (C) andthe mixture of NS and C separately. The neat culture supernatant of hybridoma showed a strong reaction with HCV capsidprotein (OD492 value > 2.0) and mixture of NS and C (OD492 value >1.5), and have noreaction with HCV Non-structural protein (OD492 value < 0.03). Not suitable for use in Western Blots. Has been used successfully in the recognition of in-vitro translated HCV core protein.

Restrictions: For Research Use only

Stockage

Reconstitution: Restore with Double distillated water to adjust the final concentration to 1.0 mg/mL

Buffer: 0.01 M PBS, pH 7.0 without preservatives.

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: Store the antibody at -20 °C. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur HCV Core Protein

Antigène: HCV Core Protein (HCV C) (Hepatitis C Virus Core Protein (HCV C))

Autre désignation: HCV Core Protein

Classe de substances: Viral Protein

Sujet: The hepatitis C virus (HCV) core protein represents the first 191 amino acids of the viral precursor polyprotein and is cotranslationally inserted into the membrane of the endoplasmic reticulum. Hepatitis C virus (HCV) core is a viral structural protein, it also participates in some cellular processes, including transcriptional regulation. However the mechanisms of core-mediated transcriptional regulation remain poorly understood. Hepatitis C virus (HCV) core protein is thought to contribute to HCV pathogenesis through its interaction with various signal transduction pathways. In addition, HCV core antigen is a recently developed marker of hepatitis C infection. The HCV core protein has been previously shown to circulate in the bloodstream of HCV-infected patients and inhibit host immunity through an interaction with gC1qR. Hepatitis C Virus is a positive, single stranded RNA virus in the Flaviviridae family. The genome is approximately 10,000 nucleotides and encodes a single polyprotein of about 3,000 amino acids. The polyprotein is processed by host cell and viral proteases into three major structural proteins and several non structural proteins necessary for viral replication. Hepatitis C virus (HCV) causes most cases of non-A, non-B hepatitis and results in most HCV infected people developing chronic infections, liver cirrhosis and hepatocellular carcinoma. T cell responses, including interferon-gamma production are severely suppressed in chronic HCV patients.Synonyms: Hepatitis C Virus core protein