HCV Core Protein anticorps

N° du produit ABIN452511

Cet anticorps anti-HCV Core Protein Monoclonal Souris (Clone B2) (ABIN452511) détecte spécifiquement HCV Core Protein dans WB et EIA. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour HCV Core Protein anticorps (ABIN452511)

Antigène: HCV Core Protein (HCV C) (Hepatitis C Virus Core Protein (HCV C))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp HCV Core Protein est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Clone: B2

Détail du produit anti-HCV Core Protein anticorps

Réactivité croisée (Details): Species reactivity (tested):Human.

Attributs du produit: Synonyms: Hepatitis C Virus

Purification: Affinity chromatography on Protein G.

Immunogène: Synthetic peptides derived from HCV Capsid Protein.

Isotype: IgG1

Information d'application

Indications d'application: ELISA: React with Human Hepatitis C Virus core protein, and no reaction with HCVnon-structure protein. Western Blot: Use of anti-HCV Core Protein antibody at 0.1-0.5 μg/mL will allowvisualization of 0.1 μg/lane of recombinant Capsid Protein (CPC)+Envelope protein M (EPM)(core), 0.5 μg/lane synthetic CPC, and 0.1 μg/lane recombinant chimeric HCV polyprotein. Testing is under both reducing and non-reducing conditions. Has been used successfully in the recognition of in-vitro translated HCV core protein.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: 0.01 M PBS, pH 7.0 without preservatives.

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: Store the antibody at -20 °C. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur HCV Core Protein

Antigène: HCV Core Protein (HCV C) (Hepatitis C Virus Core Protein (HCV C))

Autre désignation: HCV Core Protein

Classe de substances: Viral Protein

Sujet: The hepatitis C virus (HCV) core protein represents the first 191 amino acids of the viral precursor polyprotein and is cotranslationally inserted into the membrane of the endoplasmic reticulum. Hepatitis C virus (HCV) core is a viral structural protein, it also participates in some cellular processes, including transcriptional regulation. However the mechanisms of core-mediated transcriptional regulation remain poorly understood. Hepatitis C virus (HCV) core protein is thought to contribute to HCV pathogenesis through its interaction with various signal transduction pathways. In addition, HCV core antigen is a recently developed marker of hepatitis C infection. The HCV core protein has been previously shown to circulate in the bloodstream of HCV-infected patients and inhibit host immunity through an interaction with gC1qR. Hepatitis C Virus is a positive, single stranded RNA virus in the Flaviviridae family. The genome is approximately 10,000 nucleotides and encodes a single polyprotein of about 3,000 amino acids. The polyprotein is processed by host cell and viral proteases into three major structural proteins and several non structural proteins necessary for viral replication. Hepatitis C virus (HCV) causes most cases of non-A, non-B hepatitis and results in most HCV infected people developing chronic infections, liver cirrhosis and hepatocellular carcinoma. T cell responses, including interferon-gamma production are severely suppressed in chronic HCV patients.Synonyms: Hepatitis C Virus core protein