Aflatoxin anticorps

N° du produit ABIN452582

Détail du produit anti-Aflatoxin anticorps

Antigène: Aflatoxin (AFT)

Reactivité: Aspergillus

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp Aflatoxin est non-conjugé

Application: Lateral Flow (LF), Enzyme Immunoassay (EIA)

Purification: Affinity Chromatography on Protein G.

Immunogène: Winstar rats were immunized with Aflatoxin M1-BSA conjugate.

Clone: 2-00E-004

Isotype: IgG2b

Information d'application

Indications d'application: ELISA: 100 ng of AFM1 can be detected as competitive conjugate.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Reconstitution: Restore with double distillated water to adjust the final concentration to 1.0 mg/mL.

Buffer: 0.01 M PBS, pH 7.2 without preservatives

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: Store the antibody in aliquots at -20 °C after reconstitution. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur Aflatoxin

Antigène: Aflatoxin (AFT)

Autre désignation: Aflatoxin (AFT Produits)

Classe de substances: Chemical

Sujet: The aflatoxins are a group of closely related mycotoxins that are widely distributed in nature. The most important of the group is aflatoxin B1 (AFB1), which has a range of biological activities, including acute toxicity, teratogenicity, mutagenicity and carcinogenicity. In order for AFB1 to exert its effects, it must be converted to its reactive epoxide by the action of the mixed function mono-oxygenase enzyme systems (cytochrome P450-dependent) in the tissues (in particular, the liver) of the affected animal. This epoxide is highly reactive and can form derivatives with several cellular macromolecules, including DNA, RNA and protein. Cytochrome P450 enzymes may additionally catalyse the hydroxylation (to AFQ1 and AFM1) and demethylation (to AFP1) of the parent AFB1?Molecule, resulting in products less toxic than AFB1. Conjugation of AFB1 to glutathione (mediated by glutathione S-transferase) and its subsequent excretion is regarded as an important detoxification pathway in animals.