FOXE1 anticorps (C-Term)

N° du produit ABIN452689

Cet anticorps Chèvre Polyclonal détecte spécifiquement FOXE1 dans IHC (p) et EIA. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour FOXE1 anticorps (C-Term) (ABIN452689)

Antigène: FOXE1 (Forkhead Box E1 (Thyroid Transcription Factor 2) (FOXE1))

Reactivité: Humain

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp FOXE1 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Détail du produit anti-FOXE1 anticorps

Épitope: C-Term

Specificité: Recognizes FOXE1 / TTF2 at C-term.

Réactivité croisée (Details): Species reactivity (expected):Bat, Elephant, Marmoset, Gorilla, Monkey, Rabbit.
Species reactivity (tested):Human.

Purification: Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide.

Immunogène: Peptide with sequence C-AYPGGIDRFVSAM, from the C Terminus of the protein sequence according to NP_004464.2. Genename: FOXE1

Information d'application

Indications d'application: Peptide ELISA: Limit Dilution: 1/32000. Western blot: Preliminary experiments gave an approx 70 kDa band in Human Thymus andThyroid Gland lysates after 0.3 μg/mL antibody staining. Please note that currently wecannot find an explanation in the literature for the band we observe given the calculated

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Détails sur FOXE1

Antigène: FOXE1 (Forkhead Box E1 (Thyroid Transcription Factor 2) (FOXE1))

Autre désignation: FOXE1 / FKHL15

Sujet: Forkhead box protein E1 (FOXE1) is a member of the forkhead/ winged-helix domain transcription factor family. FOXE1, also designated FKHL15 or TTF-2, complexes with TTF-1 and Pax-8 to induce thyroid follicular cell differentiation and thyroid hormone biosynthesis by regulating the expression of the sodium iodide symporter (NIS), thyroid peroxidase (TPO), thyroglobulin (TG) and the thyrotropin receptor (TSHR). FOXE1 encodes a protein that is expressed in several tissues, including thymus, adult brain, lung, liver, heart and pancreas. The chromosomal location of the FOXE1 gene on 9q22 suggests that it may be involved in squamous cell epithelioma and hereditary sensory neuropathy type I. Mutations in the FOXE1 gene lead to the development of congenital hypothyroidism, which occurs in approximately one in four thousand newborns and results in complete or partial failure of thyroid gland development. Patients who are homozygous for a missense mutation in the forkhead domain of he FOXE1 gene can also develop thyroid agenesis, cleft palate and choanal atresia. Subsequently, the FOXE1 gene may used as a marker to study these disorders.Synonyms: FOXE2, Forkhead box protein E1, HFKH4, HFKL5, HNF-3/fork head-like protein 5, TITF2, TTF-2, TTF2, Thyroid transcription factor 2

ID gène: 2304

NCBI Accession: NP_004464

UniProt: O00358